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Welcome to OsteoNaturals. We invite you to shop our online store for quality nutritional supplements that promote skeletal health. In addition, our site is full of useful information about osteoporosis and insights about how it can be managed naturally.

Individuals who intend to stay active into retirement will need strong, healthy bones, and a strategy for maintaining muscle strength and overall fitness. Whatever your age or current condition, it is never too early or too late to make a positive difference. The "OsteoNaturals difference" = natural ingredients chosen for quality, safety, purity and potency.


Tuesday, September 5, 2017

DX Severe Osteoporosis: Part IV -- Zebras



The Will

"Sometimes you don't know how deep inside you can go until you put yourself in a place where there is nothing between you and the mirror in front of you to blur the image; a mirror that shows not just your form, but your capacity--what you are made of. To give off light, along with passion you also need will. Will carries you through hard times and loneliness when no one else believes you can accomplish what you have set out to do. The will focuses the flare of passion, it is your navigator, the director of our life force, the hands that tend your flowering. Like the skeleton, will gives you form. It doesn't just support your movements, nor is it just a reflection of your musclular capabilities, but your will defines the absolute raw intensity of your nature, and by this you can bring into being all that lies within you as potential."
Crucibles of Will


This is Part IV of a multi-part essay telling you about my own personal experience with osteoporosis.


Zebras

After receiving "the diagnosis" I realized I had been getting signals for some time that something was wrong. My hands and lower back ached constantly; I had about as much energy as a dog in August; and felt cold all the time, as if it were perpetually January. My skin, especially on my chest and arms was incredibly sensitive and I hated being touched in these places. I was irritable and I guess I was depressed, although I would have denied it completely. Sharp noises or gentle pokes from my children during play caused a sickening wave of adrenaline response to course through me. The two fractured ribs I sustained while training for the American Berkebeiner, a 50-kilometer cross-country ski race in Wisconsin, now made more sense. I had just been pulling hard on the ski poles going up the hills...no falls, no direct trauma; just intense muscular shear forces on the now obviously structurally unsound bone.

The newly discovered frailty also began to take its toll on my professional life as a chiropractor. Every time I entered a treatment room I felt as if I were taking on a sumo wrestler...heaven forbid if the patient was 6 feet plus and weighed over 200 pounds. Chiropractic treatment in general is very precise and gentle, but it does require some motions that impart more physical stress to the doctor than they do to the patient. Even when treating normal-sized adults, adjusting them would send shock vibrations rattling through me. It was as if my resilience and strength had faded away, and it wasn't the running shoe that was broken down in the morning, it was me.

Lab tests are an important source of information, not only about what is going on inside a body, but also about what isn't going on. Over the next five years laboratory testing would play a huge part in my life as I tried desperately to find out not only why I had osteoporosis but how to fix it.  Severe osteoporosis (-4.3 T score on bone density examination) in a relatively young male is rare. For several weeks after the initial diagnosis the endocrinologist thought there may be a more serious disease process lurking and that it was the source of the unusually severe bone theft from my body. The list of diseases that can cause extensive bone loss is very long. From the common condition where one of the parathyroid glands becomes overactive (hyperparathyroidism), to the deadly bone-destroying multiple myeloma. We had to rule each of them out. Initial lab work helped eliminate most of the dreaded disorders. The only real clues we came up with were that my urine was rich in calcium and had large amounts of bone collagen in it, the result of active bone destruction--way too much of it.

There is an old saying, "When you hear hoof-beats, don't think zebras." In other words, if you hear hooves behind you, don't expect to see a zebra when you turn around...it will probably just be a horse. Dr. Theodore Woodward, a medical doctor in the 1940s, coined this phrase as a way of encouraging fellow doctors not to delay treatment by looking for rare, complex diseases at the beginning of the differential diagnostic process, because in all likelihood, the patient's symptoms are probably being caused by something simple and easy to treat. There is a lot of truth to this...although sometimes, there are zebras.

To rule out the systemic mastocytosis the doctors had to drill a hole through my bone and take out a core sample to look at under a microscope. As an added benefit to this procedure, it was also a good way to see how my bones were really holding together and to assess the quality of my bones. 

Normal bone on the left. My biopsy on the right.
During the two weeks before the biopsy, I took two short courses of oral tetracycline. This would be absorbed into my bones and used as markers for the lab to determine the pace at which my bone was being made. The bone tissue was taken from the right side of my pelvis. The surgeon from UConn Health Center first injected a local anesthesia into the area, made a small incision and then, with a hollow hand-drill called a trephine, began drilling through the bone. The trephine was shiny but still medieval-looking, and had a rudimentary handle on one end with large jagged teeth on the other. The doctor took her time twisting the trephine; I could feel the teeth as they passed through each layer of bone. She explained that it was easy to damage the sample; osteoporotic bone is fragile, especially the trabeculae--the lattice of three-dimensional structural beams sandwiched between the inner and outer cortex that give bone its ability to be light yet strong. Trabeculae are designed to withstand the forces of normal activity, like running, but not drilling. If she used too much force, the trabeculae would snap and the pathologist would not get a good picture of their integrity, their "connectivity."

I must admit, having a hole drilled through my pelvis was unnerving. I know it really wasn't a major procedure, patients have a lot worse things done to them. It didn't even hurt that much except for the injections of anesthesia through my abdomen to help numb the inner part of my pelvic bone. But the whole procedure just seemed crude. My response had nothing to do with the doctor; she was extremely sensitive, caring and competent. Maybe it was the sedative she gave me, but during the surgery I kept thinking about the ancient Indians of South and Central American, and how archeologists have discovered skulls with holes drilled into them. Holes that had healed around their edges, indicating that the people/patients had been alive when the procedures were performed. Although they were performed with the intention to heal, it had to have been excruciatingly painful--such an invasion, an assault upon those individuals. What was being done to me had been done to them long before--the drilling-- the same procedure of a person twisting a tool into the inner physical being of another.

The doctor finally broke through the inner bone cortex to the softer tissues underneath, and pulled out a 3/4 inch, pencil-thick, piece of bone. She placed it carefully into a small bottle of chemical solution and handed it to me. I had never seen a piece of my body like that before. It was all so odd to me.

I had been told that the aftereffects would not be any worse than if I had bumped my hip into a kitchen counter. That description might have been accurate, but only if I had been running twenty m.p.h. through my kitchen when I hit it. For the next three days I dragged my leg around like a lead weight; I couldn't even think about running for two weeks.

Trabeculae in bone should be plentiful, robust, and intact. What we found when we looked at the biopsy slides was that mine were few in number, thin, and disconnected. In a crime lab with just bone to look at, a technician would have pinned me as a 100-year-old malnourished female. Rapid loss of bone does that to trabeculae. When osteoclasts become aggressive, devouring excess bone and leaving large deep gouges in the bone surface, even normal functioning osteoblasts are incapable of fully filling in the holes with new bone. The result is pitting in the cortex of the bone and trabeculae that get thinner and thinner until they separate from adjacent bone.

Looking at my bone biopsy under the microscope, we could see a lot of the trabeculae just hanging there like stalactites and stalagmites giving no strength at all to the bone. It was similar to the beech trees in New England that become weakened by a fungal pathogen. Hidden from view just under the bark, the beech's inner structural core is silently being eaten away. To the untrained eye, the trees appear healthy enough, beautiful majestic giants in the forest, until a small wind topples them over...the result of "beech snap." Osteoporosis is similar. Often silent, often afflicting healthy appearing individuals, but underneath hidden from view are overzealous osteoclasts eating away, like a fungus, at the structural core.

As with the wood in "beech snap," trabeculae, in osteoporotic bone, become incapable of resisting the stresses of everyday life. Hips snap and the spine crumbles, and like the broken beech that can't regenerate, the trabeculae can never re-attach. The manner by which bone forms does not allow for it to develop where there is nothing but empty space. This is where all those articles I had read about severe bone loss being "irreversible," began to make sense. But I did not want to accept that. I wanted to find a way around this seemingly impossible physiological impasse. There had to be a way, not just to gain back density by using a drug, but to gain back both the bone density and the structural integrity of newly remodeled bone.

The biopsy ruled out mastocytosis but actually brought up more questions than it did answers.
Zebra striping. Intermittent bone formation.
Besides having disconnected trabeculae, my bone had an odd appearance. The biopsy report called it "zebra striping," or intermittent bone deposition. There would be up to four layers in some areas, with new bone and then no mineralized bone, then bone, then no mineralized bone. It looked like the layers of different soils at an archeological dig. The endocrinologist estimated that the time-lapse between each stripe was days or weeks, not months. Neither the pathologist who read the biopsy nor my endocrinologist knew what to make of the queer stratification. They had seen this striping before on rare occasions with metal toxicity, but the biopsy had been stained for aluminum and iron and it came out negative. Lab testing of blood, urine, and hair for other heavy metals came up negative as well.

It was becoming clear to me that the only way to track down and destroy the beast that stole my structural strength was to immerse myself deep in the study of osteoporosis. I wasn't about to leave this solely in the hands of doctors who would drop me into a file drawer and leave me there for weeks and months at a time. I began to read everything I could about bone biology, and specifically, osteoporosis. I went to osteoporosis seminars and week-long conventions. I took courses on how to read bone density exams. I joined the American Society for Bone and Mineral Research, the International Bone and Mineral Society, and the International Society for Clinical Densitometry. I had dissected a lot of human cadavers in anatomy class at chiropractic school so I knew what it was like not only to study something intensely, but to pick through each and every part of a very complex puzzle. I wasn't just going to study this disease, I was going to rip it apart, piece by piece, clue by clue. Like a dog kicked into a corner, (s)he will come out fighting. I may have skipped a few beats when I first heard the words "severe osteoporosis" as my diagnosis, but my heart quickly rebounded, pounding like a competition-starved athlete ready to do battle. I was sure this beast wasn't much tougher than some of the big ugly guys I had competed against when I was vying for a spot on the USA Olympic Team. I might not win but I sure as hell would attack with everything I had, even down to the center of my physical being, down to my bones. Or at least what was left of them.

"When you go to the core of anything, you go to the heart of its reality, its truth, its real substance."



Saturday, September 2, 2017

Is Prolia the right choice to help reduce fracture risk ???

When faced with fractures from severe osteoporosis, taking a bone specific medication to gain bone density (and hopefully bone strength) can be warranted, at least in the short-term. Prolia (denosumab), or one of the four available bisphosphonate medications on the market, are typically the options given by medical doctors for treatment of osteoporosis. None of these drugs are great--they can all cause mild to severe adverse side effects and long-term use can lead to atypical femur fractures and osteonecrosis of the jaw (ONJ)--but in some severe cases, when fracture risk is extremely high, we just have no choice but to use a medication. More and more doctors are beginning to prescribe Prolia, and less so the bisphosphonates. The reason for this is that studies show Prolia to increase bone density more so than the bisphosphonates. But...there is a hitch. (There usually is when it comes to drugs.)

Prolia is a human monoclonal antibody that inhibits an immune protein called RANKL. (Dr. McCormick talks about RANKL in his book, The Whole-Body Approach to Osteoporosis.) RANKL stimulates osteoclast cells to
resorb (break down) bone. By limiting the body's ability to produce RANKL, Prolia is able to effectively reduce osteoclastic bone resorption and increase bone density. The problem is that RANKL is also needed for the immune system to work properly. So by limiting RANKL production we see immune related side-effects such as muscle and joint pain (inflammation), nausea, diarrhea, headache, skin irritation, skin blistering, fever/chills, dizziness, numbness, urinary tract infections, abdominal pain, elevated heart rate...etc....etc....

But side-effects may not be the worst thing about USING this drug...it may be from STOPPING this drug. In a review of the literature, the European Calcified Tissue Society (ECTS) found that when Prolia is discontinued there is "a rapid decrease of bone mineral density (BMD) and a steep increase in bone turnover markers (BTMs)". Case studies show "multiple vertebral fractures, after discontinuation of denosumab."

Analysis of the FREEDOM and FREEDOM Extension Trial suggests "the risk of multiple vertebral fractures may be increased when denosumab is stopped due to a rebound increase in bone resorption." "Clinicians and patients should be aware of this potential risk."

This rebound effect makes taking Prolia short-term not an option unless it is backed up by a minimum of 6 to 12 months of a bisphosphonate.

Tsondi, E. et al. 2017. Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS,
Bone Aug 5;106:11-17.

Wednesday, August 30, 2017

DX Severe Osteoporosis: Part III -- Looking to the "Whole" for Answers




"It is not by sending his awareness out beyond the natural world that the shaman makes contact with the purveyors of life and health, nor by journeying into his personal psyche; rather, it is by propelling his awareness laterally, outward into the depths of a landscape at once both sensuous and psychological, the living dream that we share with the soaring hawk, the spider, and the stone silently sprouting lichens on its coarse surface."


     David Abram, 

     author of The Spell of the Sensuous



This is Part III of a multi-part essay telling you about my own personal experience with osteoporosis.



Part III :  The "Whole"

I knew from the start that I wanted to be informed about, and involved in, every aspect of testing, diagnosis, and the development of a treatment plan for my osteoporosis. Anyone can choose to do this, if she or he is willing and able to put in the time and attention. It was somewhat easier for me because of my medical training but I still struggled and I knew it was important to get the expert help of specialists. The specialists were allies in unknown territory for me. I rounded up the best I could find. I put together my own team to go up against this disease that was my new adversary.


The fourth endocrinologist that I contacted (I found out later) was the "Godfather" of osteoporosis. A doctor world renown for his expertise in osteoporosis and who ended up being not just an amazing doctor to me but also my mentor. I also saw several additional orthopedists because I not only had osteoporosis but my hip pain persisted beyond the time when the micro-fractures should have healed.


While the specialists gave me useful information (especially the endocrinologist) it could be frustrating to try to communicate with them. The very focus that made them experts in their fields seemed to give them a kind of blindness. It was as if they could only see from one point of view, the view given them by their specialty. To me it made sense not to confine my vision to one viewpoint, but to consider my body as a whole. After having been active all my life, I was not used to being shut down physically. Now I had two chronic disorders at once, the hip pain and the bone loss. This got me thinking--could there be a connection between the two? Not that one was necessarily causing the other--the micro-fractures and osteoporosis, yes, but the persistent hip inflammation and severe bone loss?...well...could THEY be from the same underlying mechanism? Could these two entities be caused by the same "poison in the water"?


I put this question to the different specialists I was seeing: a new orthopedist and his in-residency assistant at Boston General Hospital, and also to the endocrinologist at UConn Center for Osteoporosis. But each of them just looked through the eyes of his own specialty. The two orthopedists thought only in terms of bones and joints, focusing totally on the hip inflammation. They ruled out arthritis and Lyme disease, and never once mentioned the word osteoporosis and certainly didn't consider the possibility that there could be a deeper connection between the two entities on the biochemical or body systems level. The endocrinologist thought only about hormonal and metabolic disease processes within the organs that can cause a loss of bone density. He never thought to look at the persistent inflammation in the hip for any clues that might help him find the reason for the osteoporosis.


Like race horses wearing blinkers, if it wasn't right in front of them, if it wasn't in their specialty, then it didn't exist. My suggestion of a possible underlying condition contributing both to the lingering inflammation in the hip and the systemic osteoporosis would have involved crossing lines between specialties. Their minds just could not do that. Modern Western medicine is so bound up in its own laws of associating particular symptoms with particular disease conditions and commonly associated causal factors, that physicians often resist considering any alternate possibilities of connection.


The problem with how the specialists looked at things seemed to be a case of hyper-focus. But when you are looking at your own predicament and trying to find answers, immediate answers, it goes beyond hyper-focus, it goes into desperation. Having that feeling of desperation and focusing too intensely in your effort to find an answer can, and usually does, interfere with your ability to see something that is right in front of you.


Caught in a crisis, desperate for solutions -- solutions now--
it is hard for the mind to let go of the sharp focus. We feel that that intensity of focus is the only way to solve the problem. But in truth, we need to widen our view. We need to stand back--decipher the significant reality that may be cluttered, camouflaged, distorted by dogma and our own hyper-reactive emotions, and take in the "whole" view. In my own practice as a chiropractic physician, I have seen that pushing to make a diagnosis too soon can lead to error. Simply holding the pieces of the puzzle for a few hours or days can help to make the connections between patients' symptoms and my examination findings become clearer. Forcing puzzle pieces together doesn't work. By holding single threads of information, such as the appearance of an x-ray or various results from the lab, and then allowing your focus to widen--to let connections between threads or dangling pieces become clearer--the connections will eventually evolve and become locking pieces to the puzzle. It is by gong back and forth between sharp focus--wide focus--sharp focus, that you allow the diagnosis to develop. It takes time and patience to let the pervasive pattern of energy that runs through each person's system help in connecting the pieces into a whole. All my experience told me that I needed to bring a different kind of vision to the problem of my osteoporosis than that one on which the specialists relied.


I began to see that the trail to recovery would be long. That those moments when I had stood with the two initial orthopedic surgeons looking at the dark x-ray of my hip, that I was standing at the beginning of a long trail through difficult terrain that might (and did) extend for years. Academically speaking, the trail was choked with a tangle of medical information that was hard to decipher. But even more difficult was the psychological challenge of this boulder strewn trail; one where I would stumble and curse through multiple fragility fractures--twelve over the next five years.  

...to be continued...


"The effects of any serious disease ripple throughout our bodies, throughout our lives--throughout everything we think of as the self."
Crucibles of Will





Wednesday, August 23, 2017

DX Severe Osteoporosis: Part II -- A Burning


"Our lives are a burning. The physical processes that fuel and sustain us--breathing and eating--are kinds of burning. Our passion also is a kind of fire. When our lives are lit by our passions, they give off light and heat. In the end our bodies are consumed, and only the gold is left."
                                                                                                  R. Keith McCormick, DC
 

This is Part II of a multi-part essay telling you about my own personal experience with osteoporosis.


Part II A Burning

My first reaction was embarrassment. How could I have this? I'd eaten well all my life: or at least I thought I had. I'd always drunk a lot of milk. I'd never done anything "wrong." I'd always done everything "right" to be healthy. It just didn't make any sense. Osteoporosis--a disease associated with frailty--was the antithesis of who I thought I was. From early on, the foundation of my life centered on developing the strongest, fastest, healthiest body I could. I had always wanted to be an Olympian and it seemed that from day one my attitude had been one of wanting to improve--to be the best, strongest, toughest competitor out there. My body was the vessel by which to achieve this, and I had fueled it with those goals in mind.

I didn't tell anyone of my condition. I was too embarrassed--ashamed of what I had become--a broken-down old man in what I had thought was the prime of my life.

Initially, I struggled, not knowing how I was going to get out of this crumbling skeletal mess. Before I was diagnosed, I felt that I was almost unstoppable and certainly unbreakable. Osteoporosis did not fit with my unbreakable self-image. Now I was afraid I would fracture my spine if I opened the garage door or bent down to pick up something, and certainly shatter if I fell off my bike. Always one to help out at my son's school, moving benches, lifting boxes, building sheds, I began to hide or made excuses. I was supposed to be strong, an Ironman (triathlete), an ex-Olympian no less. And now, just like that, I couldn't move a table. Everyone would surely think I was a wimp!

The voice of the orthopedist, "You should go on disability" and "Now promise me that you'll walk with a cane," made me want to throw up. When I stood before a mirror, no matter how long I searched for that person I used to be, all I saw was emptiness. My self-confidence, as well as my inner structural core, had withered away.

The first endocrinologist I saw read down a list of about twenty diseases and risk factors that can cause severe bone loss, asking me questions after each item. When he got to the bottom of the list, he diagnosed me with "primary osteoporosis" and handed me two prescriptions. One was for a thiazide diuretic to help reduce the calcium loss in my urine, and the other for alendronate (Fosamax), a bisphosphonate to harden my bones. I told him that I wasn't there for prescriptions--I was there to find out why I had osteoporosis--and to fix it.

After calls and e-mails to three more endocrinologists, one of whom wrote back asking for the date of my last menstrual period, I finally made an appointment with one who specialized in the treatment of osteoporosis. The day of my appointment came and, as I opened the door to his waiting room, I stepped into a world that made me shudder. Trying to look invisible, I walked slowly to a chair and sat down. There were three other patients: all older women, all in wheelchairs, each with a dowager's hump indicating spinal degeneration from a series of compression fractures. All three women looked downward. The did not speak. They did not make eye contact with me or each other. Each was withdrawn as though she were collapsing inward. And then it dawned on me. These women were now my peers.

When I left that office, I never looked back. I was on a mission--a mission not only to find out everything I could about my osteoporosis and fix it, but also to gain back my lost self-confidence.

"Frailty has a way of sneaking up on a person. It's like the wear of your running shoes. Everything seems to be going along fine and then you pull up lame because your shoes have worn out -- as if the innersole somehow broke down overnight while you were sleeping."

Monday, August 14, 2017

DX Severe Osteoporosis: Part I -- The Day That Changed My Life Forever



"Glimmering on the edge of death, sweeping in to overwhelm us, is the larger sense of who we are."

   Paul Rezendes
   author of The Wild Within


This is Part I of a multi-part essay telling you about my own personal experience with osteoporosis. I'll try not to be too windy but I will take you through some of the diagnostic and treatment phases of my care. I will offer LOTS of information to help you gain a better understanding of osteoporosis in general, and hopefully even some specifics into your own bone health. 


Part I :  The Day that Changed My Life Forever


I remember the day like it was yesterday...

The doctor put the x-ray up on the view-box...the bones were not white: they were gray--like ashes.

The x-ray of my pelvis didn't light up with the brightness of hard, opaque tissue characteristic of healthy bone. It was dull, and the light that filtered through it, drained the room of substance. There had been barely enough room for an exam table and an old chair, and now it felt claustrophobic. I stood wedged between the two orthopedic surgeons, faces pale and gray in the dim, florescent, hospital light as we stared at the film showing the first hard evidence that something was seriously wrong. "The hip joint itself looks good," the senior orthopedist said, "but the bone looks rare--not much density."

It had been the pain that finally forced me to the doctor's office; the pain that had stopped my running. As an athlete who had trained intensely for over 25 years, running road races, and competing in the sports of modern pentathlon and triathlon, I was used to discomfort and nagging injuries. But this time the pain persisted in a way it never had before. It was in my hip, and at first I thought it was just another over-use injury from running.

But the severity of this injury was more than I could figure out myself...I needed some help.

One look at the x-ray showed an obvious lack of overall bone density. Where there should have been the whiteness of bone, there were the dark grays typical of softer, less-dense tissues. Later an MRI, bone scan, and two bone density exams revealed capsular synovitis with micro-fracturing of the femoral head, and severe osteoporosis of the spine and both hips. Like a ton of bricks, I was totally floored as the bone density technician unprofessionally blurted out, "you have worse bone density than a 100-year-old woman!"

How could I have osteoporosis? I was a 46-year-old man, I had been active all my life, and I had always tried to live a healthy life-style. It seemed to me that nothing I had done had invited this disease, and that I had done a lot that should have prevented it. But here it was. It was too late to shut the door in its face. It had already moved in and was making itself at home. Now I had to figure out how to live with it, how to limit the damage, and how to stop it if I could. And I had to figure it out fast--before it ate away my bones.

(to be continued)

Wednesday, July 12, 2017

N-acetyl cysteine (NAC) is powerful therapy for osteoporosis

N- acetyl cysteine (NAC) is an amino acid with powerful antioxidant activity. Like other antioxidants, NAC can help prevent inflammation and cell damage from free radicals but its healing powers do not stop there. NAC has been shown to be especially helpful at combating bone loss. Studies by Ji, et al (2011) and Yamada, et al (2013) both showed that NAC reduces bone loss from excessive osteoclastic activity, increases bone formation, and lowers fat infiltration into bone marrow which can crowd out bone forming osteoblast cells. By neutralizing free radicals and pro-inflammatory cytokines, NAC can be important therapy for combating osteoporosis. Using rat cell cultures, Yamada showed that NAC can help regenerate bone and concluded that "NAC can function as an osteogenesis-enhancing molecule to accelerate bone regeneration by activating differentiation of osteogenic lineages." Ji concluded that "NAC is a promising potential drug for the prevention
and treatment of osteoporosis...".

OsteoNaturals' OsteoStim is a unique and potent blend of antioxidants, vitamins, milk basic protein and medicinal herbs designed to aid in the reduction of chronic inflammation, encourage normal bone metabolism, and manage the adverse metabolic processes of osteoporosis. It contains a therapeutic dose of 600 mg N-acetyl cysteine.  Three caplets provide:
  • Vitamin D3 (1,000 IU): For improved absorption of calcium. Associated with higher bone mineral density and lower fracture risk. Promotes muscle strength and decreased risk for falls. 
  • Vitamin K2 (MK4 (700 mcg) and MK7 (50 mcg)): Activates osteocalcin, a protein important for bone formation. 
  • Biotin (3,000 mcg): Necessary for cell growth. 
  • Alpha-Lipoic Acid (200 mg): Powerful antioxidant to help reduce the proinflammatory 
  • cytokines that stimulate osteoclastic bone resorption and excessive bone loss. 
  • N-Acetyl Cysteine (NAC) (600 mg): This powerful antioxidant lowers free radicals, major contributors to excessive bone loss. 
  • Taurine (200 mg): Important co-factor for balanced bone remodeling activity. 
  • Berberine (250 mg): Studies indicate this medicinal herb helps prevent bone loss and increase bone mineral density by promoting osteoblast (bone-building cells) formation. 
  • BioferrinⓇ 1000 (250 mg): A low-iron (apo-lactoferrin) natural, biologically active milk protein isolated from whey for reducing oxidative stress, decreasing inflammation, and promoting improved bone mineral density. 
  • MBP® (Milk Basic Protein) (40 mg): A component of milk whey shown to promote bone formation and inhibit bone resorption.* 
  • Milk Thistle (200 mg): Medicinal herb with powerful antioxidant activity to help limit the activity of bone-resorbing osteoclasts.
  • GMO and gluten free.

Yamada, M., et al. 2013. N-acetyl cysteine as an osteogenesis-enhancing molecule for bone regeneration. Biomaterials May 24 [Epub ahead of print].

Ji, H., et al. 2011. N-acetyl-L-cysteine enhances the osteogenic differentiation and inhibits the adipogenic differentiation through up regulation of Wnt 5a and down regulation of PPARG in bone marrow stromal cells. Biomed Pharmacother Aug:65(5):369-74.
 

Sunday, July 9, 2017

Calcium-rich, marine multi-mineral complex (Aquamin) is superior to calcium carbonate in its ability to slow bone loss

In a recently published study in Calcified Tissue International, Orlaith Brennan (Royal College of Surgeons, Ireland) and colleagues, compared the calcium-rich, marine multi-mineral complex, Aquamin to calcium carbonate in an ovariectomised rat model of osteoporosis. The purpose of the
study was to assess Aquamin's efficacy in preventing bone loss. Aquamin is a natural, multi-mineral supplement derived from the red algae Lithothamnion corallioides. Aquamin is rich in calcium, magnesium, and 72 other trace minerals.

This 20-week study compared Aquamin to calcium carbonate in their influence on the mineralization and metabolic activity of osteoblasts (the cells that form bone) in cell culture. Trabecular architecture, bone composition, and the mechanical strength properties were assessed. The study found that "oral ingestion of Aquamin results in less deterioration of trabecular bone structure, mineral composition and biomechanical properties in the tibia of rats following ovariectomy than calcium carbonate." In this animal model of osteoporosis, Aquamin was shown to be superior to calcium carbonate in its ability to slow down the onset of bone loss.

OsteoNaturals' OsteoMineralBoost supplies 250 mg Aquamin.

Brennan, O., et al. 2017. A natural, calcium-rich marine multi-mineral complex preserves bone structure, composition and strength in an ovariectomised rat model of osteoporosis. Calcif Tissue Int. DOI: 10.1007/s00223-017-0299-7.
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