(10 customer reviews)

OsteoStim supplements are a potent blend of antioxidants, vitamins, milk basic protein and medicinal herbs uniquely formulated to encourage normal bone metabolism (bone resorption and formation), support individuals with low bone density (osteopenia and osteoporosis), and manage the metabolic processes of osteoporosis.


OsteoStim® supplements are a potent blend of antioxidants, vitamins, milk basic protein and medicinal herbs uniquely formulated to encourage normal bone metabolism (bone resorption and formation), support individuals with low bone density (osteopenia and osteoporosis), and manage the metabolic processes of osteoporosis.

Non-GMO and Gluten Free

OsteoStim supplements are uniquely formulated to encourage a balanced bone remodeling system and manage the abnormal metabolic processes related to osteoporosis. OsteoStim is especially designed for individuals with severe bone loss as it contains powerful herbs, vitamins, and bioactive compounds that help limit overactive osteoclastic bone destruction and stimulate osteoblastic bone formation.

OsteoStim includes vitamin D3, vitamin K2 (MK-4 and MK-7), biotin, alpha lipoic acid, N-acetyl cysteine, berberine HCL, MBP® (milk basic protein), L-taurine, and milk thistle extract – key effectors in the metabolism of bone resorption and formation.

This unique complex contains effective levels of compounds that help to:

  • Improve calcium absorption and reduce calcium loss in the urine
  • Dampen chronic inflammation (a cause of increased osteoclastic bone)
  • Limit NF-kB production (a key to reducing inflammation and osteoclast activity)
  • Repress PPAR-gamma activity (encourages more osteoblast and less fat cell formation in the bone marrow)
  • Activate osteocalcin production (vital for bone crystal formation)
  • Stimulate osteoblast (bone building cells) activity
  • Reduce osteoclast (bone destroying cells) bone destruction activity.

Serving Size: 3 capsules
Servings per container: 30


Supplemental Facts Amount Per Serving

Vitamin D3 1,000 IU (cholecalciferol)
Vitamin K 750 mcg (700 and 50) (K2-MK4 and MK7)
Biotin 3 mg
Alpha lipoic acid 200 mg **
N-acetyl cysteine 600 mg **
Berberine HCL 250 mg **
Curcumin Phytosome: curcuminoids and phosphatidylchoiline complex 100mg
Grape Extract (BioVin®) standardized to contain 75% polyphenols 75 mg
MBP® 40 mg (Milk Basic Protein) **
L-Taurine 200 mg **
Milk thistle seed extract 200 mg **

** Daily value not established

Other ingredients: Vegetable capsule, magnesium stearate, silicon dioxide


Info/Benefits of ingredients included in OsteoStim:

Vitamin D:
– An estimated 80% of elderly women are vitamin D deficient.
– Low levels results in reduced bone mass and poor muscle function.
– Serum vitamin D levels are associated with higher bone density.
– Doses greater than 800 IU/day of vitamin D can prevent fractures.
– Daily doses of 700 to 800 IU lowers the risk of hip fracture 26% and any non-vertebral fracture by 23% (Bischoff-Ferrai, 2005)
– Vitamin D supplementation is linked to reduced risk of falls.

Vitamin K2-MK4 and MK7:
– There are three major forms of vitamin K: vitamin K1 (from vegetables), vitamin K2-MK4 (from animal products), and K2-MK7 (from fermented soy).
– Numerous studies show the positive benefits of vitamin K for skeletal and vascular health (reduces arterial calcification).
– K2 is able to act as a cofactor for all vitamin K-required activities in the body.
– Vitamin K2-MK4 is found in mother’s milk, in eggs, and in organ meat, all key sources of nutrition in a hunter/gatherer’s lifestyle of the past a clear argument that we evolved genetically to use MK4. MK7 may have a longer half-life than MK4. Therefore, by combining the benefits of both MK4 and MK7 OsteoStim brings you greater biological benefits especially in the realm of bone health.
– Excellent for maintaining bone health and some of vitamin K1 is actually converted by the body into K2-MK4. Both vitamin K2-MK4 and MK7 are beneficial for bone health and when taken together they have an additive beneficial effect.
– Vitamin K deficiency is associated with reduced bone mineral density and increased fracture risk. (McKeown, 2002) (Feskanich, 1999) (Szulc, 1994)
– Acts as a cofactor in the gamma-carboxylation of glutamic acid residues of many calcium-binding proteins important to bone formation.
– Osteocalcin, a vitamin K-dependent protein, is necessary for apatite crystal formation and as a hormone in the stimulation of insulin release and energy metabolism.
– Low levels of vitamn K-dependent carboxylated osteocalcin or high levels of under-carboxylated osteocalcin carry an increased risk for femoral neck fracture. (Vermeer, 1991)
– Necessary for reducing renal calcium loss.

– A water-soluble B-complex vitamin, it is necessary for cell growth and stores may be lowered with increased supplemental intake of alpha-lipoic acid.

Alpha-Lipoic Acid:
– An essential cofactor for mitochondrial (energy production) activity
– Powerful antioxidant, reduces ROS (free radicals), and protects us from oxidative damage
– Helps reduce the damaging effects of pro-inflammatory cytokines (Il1, Il6) and NF-kB and their ability to hyper-stimulate osteoclast activity that results in excessive bone loss.
– Prevents osteoclast formation. (Ha, 2006) (Koh,2005) (Kim, 2006)
– Inhibits NF-kB activation by RANKL in osteoclasts and reduces ROS signaling. (Kim, 2006)

N-Acetyl Cysteine (NAC) and L-taurine:
– Helps regenerate glutathione, the body’s most powerful antioxidant
– Inhibits NF-kB
– Helps restore estrogen-dependent regeneration of glutathione peroxidase which lowers ROS and decreases osteoclastic bone resorption. (Lean, 2003) (Jagger, 2005) (Altken, 2004)
– Stimulates osteoblast cell differentiation. (Jun, 2008)

– An herb that inhibits osteoclastic bone resorption and prevents bone loss in ovariectomized rats. (Li, 1998) (Li, 1999)
– Promotes osteoblast differentiation and the formation of bone. (Lee,2008)
– Prevents glucocorticoid-induced osteoporosis by inhibiting bone resorption and improving bone formation in rats. (Xu, 2010)
– Reduces bone loss by inhibiting osteoclasts (Wei, 2009) (Hu, 2008)

(Milk Basic Protein)(MBP® is produced under multiple patents. This trademark is a registered trademark of MEGMILK SNOW BRAND CO, Ltd):
– This natural protein is a trace component of both human and bovine whey. It is unique in that it has been shown to help increase the number of bone forming osteoblast cells while simultaneously regulating excess activity of the bone destroying osteoclasts. The result, a natural stabilization of bone’s remodeling process through the promotion of bone formation and inhibition of bone resorption. Research has shown that supplementing with 40 mg/day of Milk Basic Protein increases bone density (Uenishi, 2007). Since Milk Basic Protein is a component of whey, most individuals with an allergy or sensitivity to the casein and/or lactose portions of dairy are able to tolerate this product. Individuals with a sensitivity to whey may want to avoid this product.

– Important co-factor for balanced bone remodeling activity
– Acts to enhance bone growth factors
– Stimulates osteoblast bone matrix formation and inhibits the production of osteoclasts and their excessive bone resorbing action

Milk Thistle (silymarin):
– Potent therapeutic agent promoting bone-forming osteoblasts and reducing osteoclast bone resorption in cell cultures. (Kim, 2012)
– This medicinal herb is a powerful flavonoid that helps decrease oxidative stress by replenishing the body’s stores of glutathion.
– Dietary flavonoid intakes are associated with higher bone mineral density. (Hardcastle, 2010)

10 reviews for OsteoStim

  1. Pinky Lew

    I was diagnosed with Osteoporosis in 2016 when I had a severe fracture. I tried a bunch of supplements and read a bunch of books.
    The other supplements gave me heart palpitations.
    But I take Osteostim and OsteoSustain. A few months ago I had a fall and ended up bruised everywhere and I did not break anything.
    I credit this product with protection from breaking any bones when I fell which I would have before.
    I would have broken bones if I was not taking it and I know that from experience. I am not on any Osteporosis medication either!

  2. Cyan

    This is the main supplement for those with osteoporosis. I value the work that Dr. McCormick did to make these supplements available and in the correct ratios. The Osteo line from Dr. McCormick is very convenient.

  3. James D Brassord

    This is an amazing product. Never would I have ever thought that some of the ingredients in it would be good for helping me recover from osteoporosis. But a friend of mine used it and said it really slowed down his bone loss. I am really excited about it.

  4. Eric Ch

    Great product.

  5. Ginny Gibble

    I began using OsteoNaturals with Dr. Mccormick in 2010, after a DXA Scan revealed osteoporosis in my spine. I read his book The Whole Body Approach to Osteoporosis and have followed his advice. That was five years ago and now I’m in great shape! All my tests show that I have healthy bones! I will not stop using OsteoNaturals. I recommend this regime to everyone because you learn what your body needs and test to know you are getting results.

  6. T J Wilson

    As a health care provider , I’ve been using these products from OsteoNaturals for the past 2 years. I can only say that they are by far the best I’ve found working with bone health for my patients . OsteoStim is a great supplement . I’ve researched quite a few and haven’t found a product that compares. Highly recommend adding to anyone interested in improving healthy bones.

  7. Barbara Edwards

    Great supplement for bone health

  8. Mquesnel

    Great product for prevention of Osteoporosis — especially need for those post menopausal.

  9. Alan

    I’ve been using Osteo Stim as well as Osteo Sustain since Keith (Dr. McCormick) brought them to market. If you’re like me you move quickly past any “special” supplement sold by a chiropractor or doctor. These products are the exception. If you read his book, The Whole Body Approach to Osteoporosis, you’ll see the rigor of Dr. McCormick’s hard science approach to this disease. But the proof is in the numbers. Since I’ve been using these supplements my bone markers have essentially returned to normal. I’ve known Dr. McCormick as a patient for over ten years and can’t speak highly enough as to his care and commitment. Why figure out which individual supplements you need (calcium, vitamin D, magnesium, vitamin K etc), in what quantities are appropriate and most effective, and which companies you can trust buying them from them when these products do it for you. And, as I wrote, the proof is in the numbers.

  10. Mary Knight

    Great product with positive results. I started feeling stronger and more energized after only three months. It’s now part of my daily routine.

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