Proton Pump Inhibitors Not Only Cause Osteoporosis but a New Study Points to Increased Risk for Stroke

I am continually dismayed at how many of my patients with osteoporosis are taking PPIs. They have been prescribed proton pump inhibitors by their medical physicians to help reduce stomach acid and treat the symptoms of heart burn or GERD. But PPIs have the nasty side effect of reducing bone density and increasing a person's [...]

By |2019-05-13T17:37:20-04:00December 3rd, 2016|0 Comments

Are You Taking Medications That Could Cause Osteoporosis?

Unfortunately, some medications can actually CAUSE disease. In a recent review article published in Therapeutic Advances in Musculoskeletal Diseases, Panday, Gona, and Humphrey discuss common medications that can cause bone loss. The authors emphasize the importance of being aware of this often over-looked, drug-induced, adverse side effect. Why?...Because many doctors (although they know that aging, [...]

By |2019-05-14T22:50:24-04:00November 7th, 2014|0 Comments

Bisphosphonates and Osteonecrosis of the Jaw

Osteonecrosis of the jaw (ONJ) (a painful, refractory condition where a portion of the jaw bone dies and becomes exposed) has been linked to bisphosphonate therapy in the treatment of osteoporosis. Numerous studies over the past ten years have been unsatisfactory in demonstrating the actual incidence of oral bisphosphonate-related ONJ and therefore the level of [...]

By |2019-02-18T16:08:19-04:00June 26th, 2014|0 Comments

The Future: Targeting Bone-Cracks With Drug-Carrying Nanoparticles

Take a look at the future for osteoporosis drug therapy.Research into drug delivery systems is hot, especially in the arena of nanotechnology. In a series of studies based at Penn State University and Boston University, researchers used self-powered nanoparticles to deliver medication (alendronate) right to the doorsteps of bone cracks themselves.Molecules moving inside a nanotubeInterestingly, [...]

By |2019-02-18T16:08:34-04:00September 1st, 2013|0 Comments

Hormone Therapy for Osteoporosis

The loss of estrogen production by the ovaries at menopause can have profound effects on skeletal health. Low estrogen levels in women are directly associated with lower bone mineral density and increased risk for fractures. Doctors have known this for years and in fact hormone replacement therapy (HRT) in the form of estrogen and progestin [...]

By |2019-02-18T16:08:36-04:00July 15th, 2013|0 Comments

Stem Cell Therapy for Osteoporosis

Still in its infancy but looking promising is stem cell therapy for osteoporosis. California's UC Davis is home to the Institute for Regenerative Cures, a leading player in regenerative medicine. Preliminary research with mice, published in Nature Medicine, demonstrated that bone density and strength could be improved using a molecule called LLP2A-Ale that directs mesenchymal stem cells to [...]

By |2019-02-18T16:08:49-04:00May 19th, 2013|0 Comments

Teriparatide and Denosumab Combo: Two is Better Than One

Just released online by Lancet are the 12-month findings from a study combining two osteoporosis drugs. Researchers found that by combining teriparatide and denosumab, two drugs with different mechanisms, bone density improved more than if either drug was used on its own.Findings: % improvement of bone mineral density after 12 months:Lumbar spine:  teriparatide alone 6.2%, denosumab [...]

By |2019-04-13T10:33:59-04:00May 16th, 2013|0 Comments

Zoledronic Acid: New Research

Medications play an important role in the treatment of chronic diseases, but they need to be used judiciously and wisely. A recent article on zoledronic acid (Reclast and Zometa) -- a bisphosphonate medication used to treat osteoporosis and high blood levels of calcium caused by cancer -- illustrates how a stop-gap method for one diagnosis [...]

By |2019-02-18T16:08:49-04:00May 2nd, 2013|0 Comments