One of my goals as president of OsteoNaturals is to provide our customers with up to date information about osteoporosis and therapeutic options. To do this I typically peruse hundreds of medical research articles each month while sitting in the basement of the University of Massachusetts library. Scouring PubMed for exciting (yes, I love it!) research is rewarding…and fun (yes, I’m a nerd). The more I learn about the pathophysiology of osteoporosis and possible therapeutic options–both pharmacological and nutritional–the better I can help others combat their bone loss. In the last blog, I wrote about the beneficial epigenetic effects of three biocompounds in OsteoStim. In this Newsletter I want to briefly mention two articles I came across this week, one about the bone building effects of lactoferrin and the other about alpha lipoic acid– both of which are ingredients in our OsteoStim. 
Lactoferrin is a natural protein supplied by Bioferrin 1000 in our OsteoStim product. Lactoferrin boosts bone health in two ways: 1) it stimulates osteoblast bone formation activity, and, 2) it curtails bone loss by calming aggressive osteoclastic bone resorption. The overall effect of lactoferrin is that of improving bone quality and quantity for better strength and reduced fracture risk.  
In an article from the International Journal of Biological Macromolecules, researchers explore the molecular mechanisms of lactoferrin on bone building activity. Using cell cultures, Liu, et al. (2018)  investigated the enzymatic effects of various mitogen-activated protein kinase (MAPK) pathways on osteoblast cell function. They concluded that lactoferrin induced osteoblast cell proliferation and that it is “an osteogenic growth factor” and has the potential as a “therapeutic agent to treat low bone mass in patients with diseases such as osteoporosis.” Yes, we have certainly found that to be true as we are hearing of great results from those who take OsteoStim!  
The second article is by Roberts and Moreau from the University of Nebraska. This article (2015, Nutrition Reviews) gives a fairly good explanation of the mechanisms alpha lipoic acid (ALA) has on improving bone health. This bioactive compound scavenges reactive oxygen species (ROS), disposes of heavy metals, regenerates vitamins C and E, and increases CoQ10 levels (for cell energy). ALA’s antioxidant properties and ability to reduce oxidative stress and inflammation are the reasons it has been used successfully for years to treat chronic diseases such as diabetic neuropathy and liver disease…but it also works wonders for bone. 
Oxidative stress and chronic systemic inflammation are the prime destructive forces behind the accelerated bone loss of osteoporosis. ALA reduces bone loss by lowering ROS and inflammation which creates a calming effect on hyperaggressive osteoclastic bone-resorbing activity.  
What I have found over the years is that the unique combination of ingredients in OsteoStim produces a beneficial composite effect on bone, and that “the whole is far greater than the sum of its parts”.