On March 8th you will finally be able to place your order for OsteoStim. It has been a long arduous

process, but getting things right sometimes takes time…and this certainly took more time than expected. From procuring ingredients, to manufacturing, and even to printing labels, we seemed to run into production delays all the way. But production is finally complete and we are just waiting for labels to be affixed to the bottles and shipped. We couldn’t be more excited about the final product.

As many of you know from previous Newsletters, OsteoStim will now contain another ingredient. In an ongoing effort to bring you the most effective nutrition product available for improving skeletal health, we have added a low-iron form of lactoferrin to OsteoStim.

Lactoferrin is a naturally occurring glycoprotein found in milk. It is an important part of the immune system and helps the body’s innate immune defense fight against harmful bacteria, viruses, and fungi. In addition to its antimicrobial activity, lactoferrin also helps normalize bone remodeling activity as seen in the reduction of bone resorption markers (N-telopeptide and deoxypyridinoline) and increase in bone formation markers (osteocalcin and alkaline phosphatase). (1) 

With its normalizing impact on the immune system, lactoferrin reduces chronic systemic inflammation (2) which is common in people suffering from osteoporosis. This type of inflammation is often the cause of excessive osteoclastic bone resorption and bone loss. Lactoferrin not only reduces osteoclastic activity but it is one of the few compounds that can also stimulate osteoblast cells for improved bone formation. (3) The reason we see so much periodontal disease, small bowel bacterial overgrowth, candida infections, joint inflammation, muscle pain, elevated blood sugar, depression, and fatigue in patients with osteoporosis is because these are all signs and symptoms of chronic systemic inflammation. But if we reduce the chronic inflammation (and lactoferrin does a great job at this) we also REDUCE EXCESS OSTEOCLASTIC BONE RESORPTION and improve bone, and overall, health.

But…there is one drawback to lactoferrin, especially in postmenopausal women. Lactoferrin increases iron levels in the body. With no more blood loss from monthly periods, postmenopausal women should not be taking in excess iron. For this reason, we are using a special form of lactoferrin called Bioferrin 1000 (Bioferrin is a registered trademark of Glanbia Nutritionals). Bioferrin 1000 is a low-iron form of lactoferrin called apolactoferrin. In fact, for each 100 grams of Bioferrin 1000 there is less than 15 milligrams iron. In three capsules of OsteoStim there is a therapeutic dose of 250 milligrams apolactoferrin which makes this dosage virtually iron free.

We are very proud to be able to provide you with this product.

1) Bharadwaj, S., et al. 2009. Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women. Osteoporosis Int 20(9):1603-11.

2) Bharadwaj, S., et al. 2010. Inflammatory responses improve with milk ribonuclease-enriched lactoferrin supplementation in postmenopausal women. Inflammatory Research 59(11):971-8.   
3) Naot, D., et al. 2005. Lactoferrin – A novel bone growth factor. Clinical Medicine & Research 3(2):93-101.