Wednesday, July 12, 2017

N-acetyl cysteine (NAC) is powerful therapy for osteoporosis

N- acetyl cysteine (NAC) is an amino acid with powerful antioxidant activity. Like other antioxidants, NAC can help prevent inflammation and cell damage from free radicals but its healing powers do not stop there. NAC has been shown to be especially helpful at combating bone loss. Studies by Ji, et al (2011) and Yamada, et al (2013) both showed that NAC reduces bone loss from excessive osteoclastic activity, increases bone formation, and lowers fat infiltration into bone marrow which can crowd out bone forming osteoblast cells. By neutralizing free radicals and pro-inflammatory cytokines, NAC can be important therapy for combating osteoporosis. Using rat cell cultures, Yamada showed that NAC can help regenerate bone and concluded that "NAC can function as an osteogenesis-enhancing molecule to accelerate bone regeneration by activating differentiation of osteogenic lineages." Ji concluded that "NAC is a promising potential drug for the prevention
and treatment of osteoporosis...".

OsteoNaturals' OsteoStim is a unique and potent blend of antioxidants, vitamins, milk basic protein and medicinal herbs designed to aid in the reduction of chronic inflammation, encourage normal bone metabolism, and manage the adverse metabolic processes of osteoporosis. It contains a therapeutic dose of 600 mg N-acetyl cysteine.  Three caplets provide:
  • Vitamin D3 (1,000 IU): For improved absorption of calcium. Associated with higher bone mineral density and lower fracture risk. Promotes muscle strength and decreased risk for falls. 
  • Vitamin K2 (MK4 (700 mcg) and MK7 (50 mcg)): Activates osteocalcin, a protein important for bone formation. 
  • Biotin (3,000 mcg): Necessary for cell growth. 
  • Alpha-Lipoic Acid (200 mg): Powerful antioxidant to help reduce the proinflammatory 
  • cytokines that stimulate osteoclastic bone resorption and excessive bone loss. 
  • N-Acetyl Cysteine (NAC) (600 mg): This powerful antioxidant lowers free radicals, major contributors to excessive bone loss. 
  • Taurine (200 mg): Important co-factor for balanced bone remodeling activity. 
  • Berberine (250 mg): Studies indicate this medicinal herb helps prevent bone loss and increase bone mineral density by promoting osteoblast (bone-building cells) formation. 
  • BioferrinⓇ 1000 (250 mg): A low-iron (apo-lactoferrin) natural, biologically active milk protein isolated from whey for reducing oxidative stress, decreasing inflammation, and promoting improved bone mineral density. 
  • MBP® (Milk Basic Protein) (40 mg): A component of milk whey shown to promote bone formation and inhibit bone resorption.* 
  • Milk Thistle (200 mg): Medicinal herb with powerful antioxidant activity to help limit the activity of bone-resorbing osteoclasts.
  • GMO and gluten free.

Yamada, M., et al. 2013. N-acetyl cysteine as an osteogenesis-enhancing molecule for bone regeneration. Biomaterials May 24 [Epub ahead of print].

Ji, H., et al. 2011. N-acetyl-L-cysteine enhances the osteogenic differentiation and inhibits the adipogenic differentiation through up regulation of Wnt 5a and down regulation of PPARG in bone marrow stromal cells. Biomed Pharmacother Aug:65(5):369-74.
 

Sunday, July 9, 2017

Calcium-rich, marine multi-mineral complex (Aquamin) is superior to calcium carbonate in its ability to slow bone loss

In a recently published study in Calcified Tissue International, Orlaith Brennan (Royal College of Surgeons, Ireland) and colleagues, compared the calcium-rich, marine multi-mineral complex, Aquamin to calcium carbonate in an ovariectomised rat model of osteoporosis. The purpose of the
study was to assess Aquamin's efficacy in preventing bone loss. Aquamin is a natural, multi-mineral supplement derived from the red algae Lithothamnion corallioides. Aquamin is rich in calcium, magnesium, and 72 other trace minerals.

This 20-week study compared Aquamin to calcium carbonate in their influence on the mineralization and metabolic activity of osteoblasts (the cells that form bone) in cell culture. Trabecular architecture, bone composition, and the mechanical strength properties were assessed. The study found that "oral ingestion of Aquamin results in less deterioration of trabecular bone structure, mineral composition and biomechanical properties in the tibia of rats following ovariectomy than calcium carbonate." In this animal model of osteoporosis, Aquamin was shown to be superior to calcium carbonate in its ability to slow down the onset of bone loss.

OsteoNaturals' OsteoMineralBoost supplies 250 mg Aquamin.

Brennan, O., et al. 2017. A natural, calcium-rich marine multi-mineral complex preserves bone structure, composition and strength in an ovariectomised rat model of osteoporosis. Calcif Tissue Int. DOI: 10.1007/s00223-017-0299-7.

Tuesday, July 4, 2017

OsteoMineralBoost: A Real "Boost" to Bone Health

OsteoMineralBoost was designed by Dr. McCormick to provide that extra kick to mineral intake and sustained bone health. Providing 140 mg calcium from microcrystaline hydroxyapatite (MCHA) and Aquamin, 85 mg magnesium, 250 mg of trace minerals from Aquamin, and 100 mg betaine hydrochloride, OsteoMineralBoost is one of the most important bone health products on the market.

Ingredients: 
     -  MCHA is a highly absorbable form of calcium with naturally occurring bio-active bone matrix
        proteins and growth factors.
     -  Magnesium (as dimagnesium malate) is important for bone and cardiovascular health.
     -  Aquamin won the 2016 Ingredient of the Year for Healthy Aging at the Vitafoods
        Nutraingredients Awards in Geneva, Switzerland. This award was given "in recognition of the
        strong body of scientific trail data that supports Aquamin and the positive contribution that it has
        made to health." Aquamin is a marine (red algae) multi-mineral complex with bio-active
        calcium, magnesium and 72 other trace minerals. There are over 20 published peer reviewed
        papers exploring the positive benefits of Aquamin in the areas of bone health, joint and
        inflammation and digestive health.
     -  Betaine hydrochloride to aid absorption.


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