Monday, October 16, 2017

DX Severe Osteoporosis: Part VI -- Drug Therapy, Fixing Without Healing



This is Part VI of a multi-part essay about my own personal experience with osteoporosis. I will be taking you through the diagnostic and treatment phases of my care in hopes that it provides you a better understanding of osteoporosis in general, and pearls that you can use to better your own bone health. 



"In this country we are brought up to underestimate the power of our own capacity to heal, to be ignorant of how to support and strengthen our ability to recover from illness, and to rely on external substances to counter disease, discomfort, and inadequacies of all kinds."                                 Crucibles of Will



The first endocrinologist had given me two options: either do nothing until I began to self-destruct, or immediately start taking two drugs--thiazide, a diuretic that makes you urinate more but lose less calcium, and alendronate (Fosamax), a drug that stops bone loss, boosts your density, and lowers the risk of fracture. My new doctor from UConn disagreed about the thiazide, because while it may reduce calcium in the urine it can also inhibit calcium absorption from the gut.* The alendronate though, he was in total agreement with, and said that I should start it immediately.


Medications can be incredibly dramatic and effective gifts. But most drugs don't fix things, they just interfere with bodily systems in such a way as to get a desired therapeutic effect--like taking drugs to improve one's performance in sport. Gold medals are often won with the help of chemicals because for some athletes it is simply the color at the end of the chain that is important, not how you get it. The problem with drugs, besides being illegal in sport, is that the athlete never gets to find out who they really are, what they alone can really do. They are robbed of that special feeling of truly experiencing what it is like to give their whole self to a silence, to the unknown territory of their own potential--to an emptiness into which they bring the essence of who they are and offer it to the world. 


I have always thought that it was important to pay attention to the underlying truth of any situation, and the natural integrity of other beings and of ourselves. That's one of the reasons I went into chiropractic, a drugless profession, which tries to discover the whole truth behind a person's injury or illness, and which respects the integrity of the individual's body, including that body's power to heal. Drugs certainly have their place in health care, but I feel that we should try to help people as naturally and wholly as possible--it seems like less of an insult upon the body--more pure and in harmony with the person's whole being. Growing up, I could never understand how anyone could take a drug to make them something that they were not. So being told to take alendronate before we'd even tried natural alternatives was not only difficult for me to accept as the only answer to my health problem, but my resistance also had a practical side. Once a drug therapy is initiated there is no way of assessing the effects of a natural treatment plan. 


Using bone density as an indicator of success or failure of a treatment regime for osteoporosis is impractical because density builds so slowly. But using specific lab tests to see changes in the body's physiology, changes that would be beneficial in improving bone density, is more practical. If I could see improvement in lab values as a result of natural therapy, then I would know that my biochemical patterns were shifting in a good way, becoming more balanced. Starting the use of alendronate before more information was gathered would eliminate this important guide. 


Alendronate is in the family of drugs called bisphosphonates that work by killing off (or at least making them really sick) all the osteoclasts, the cells that eat old, worn-out, and unstable bone. Normally, after the osteoclasts have resorbed the old bone, other cells, called osteoblasts, come along behind and make new, strong bone, in its place. This remodeling process is what keeps our bones healthy and resilient, and the interaction or coupling between the two cell types is a balancing act that needs to be maintained. It is precisely this coupling that the bisphosphonates disrupt. 

I felt trapped...I knew very little about osteoporosis and even less about drugs. I was concerned, fearful actually, of breaking more bones and I didn't want to fall into what looked like a big dark hole of the unknown. I was 46 years old...what were these doctors asking me to do?...take drugs for my skeleton for the rest of my life?...another 45 to 50 years?! It didn't make sense.

All my life I had tried to respect my body, both to heal and to achieve in athletic competitions, with no help from synthetic chemicals of any kind. The only substance I ever used was what came naturally inside me. Now I was being asked to participate with the doctors in doing something to my body that destroyed part of its natural functioning. If I did this, I felt I would be betraying the body I had always tried hard to respect and improve. 


The problem with bisphosphonates, and the newer drug Prolia, is that they shut down bone resorption but do nothing to encourage osteoblasts to form bone. In fact, it's the osteoclasts that normally signal the osteoblasts to make new bone. With the osteoclasts gone from the scene, new bone just doesn't get made. The overall effect is a decrease in bone remodeling with minimal increase in bone density. The reason bisphosphonates are able to reduce fractures is not from their paltry increase in the density of bone (which, is secondary in nature...in other words it isn't primary new bone, just a secondary sprinkling of minerals onto the old weak scaffolding), but from a reduction in the number of small cuts of gouged out bone that the osteoclasts ordinarily make. Like the perforations that make it easy to tear pages from a notepad, these spots are vulnerable to fracture, even though they are a necessary part of remodeling. Where there is no remodeling, there are no temporary weak spots, and no focal areas where a little crack can get started. In normal bone these small cuts pose no problem, but if the overall density and strength of bone is low, these perforations become the ideal sites for catastrophic fractures to begin. 

Older people are typically more sedentary and place less stress on their skeleton. Leaving the old bone in place by stopping remodeling, seems to work well in reducing the risk of fracture, even though the actual quality of the patient's bone becomes arguably worse. How many years can a person go without remodeling before that old bone becomes so old that it's more fragile than new bone would be with remodeling sites? That's a big question and nobody knows the answer. For an 80-year-old it's probably a reasonable risk. For a 46-year-old, it's a question that hadn't been tested much, and I wasn't sure I wanted to volunteer to be a guinea pig. 

The UConn doctor was concerned that I was going to start getting some major fractures. Besides the two ribs from skiing and the new compression fracture from lifting the couch, I snapped two more ribs just leaning up against a horse to pick out its hooves...heard them snap, as easily as twigs on a dead pine. The literature was daunting; it referred to bone loss such as mine as irreversible. That's one really ugly word, irreversible. It's like saying some runner is
My biopsy with disconnected trabeculae
unbeatable...so there's no point in even trying...no point in even entering the race. The bone loss is considered irreversible because once the trabeculae, the small structural supports that give strength to inner bone are resorbed and become disconnected from surrounding bone, there is no way for new ones to reform. And when the new ones can't form, and old ones don't repair, the density just keeps going down and the risk of fracture keeps going up.


Irreversible...unbeatable...

But everyone can be beaten; maybe not by me, but by someone. I finished back in the pack in a lot more races than I ever won, but even when it looks like you can't win, you don't know till you put yourself out there and run till you drop. It is sure a lot better to get on the starting line even if you only finish second or third, or last, than it is to just sit and think about it. With osteoporosis, it was even hard to tell who was toeing the line, what I was racing against--but I knew I wasn't going to let this "irreversible" hype make me shy away from trying. I wanted to heal my body, not just take some calcium and hope for the best, and not just take some drugs that killed off some of my cells, interfered with my body's natural processes, and made my bones old. 

I knew no one was going to be committed to this program except me. But I was ready to give it everything I had. It wasn't long before I started ordering a lot of my own lab tests and researching osteoporosis using every source I could find.

One of the first tests the doctor from UConn had ordered was N-telopeptide (NTX), a bone resorption marker that measures how much bone collagen is in your urine. When the osteoclasts tear down old microfractured bone, the shards of bone collagen go into the blood and is then flushed out of the body through the urine. If the lab results for NTX come back elevated, it means the osteoclastic activity is excessive and you are loosing bone rapidly. Rapid bone loss is a major risk factor for fracture and the higher the NTX the greater the risk of breaking something. In fact, if you take two people, both the same age, same build, same everything...and they have the same bone density...the one with the higher NTX will have a greater risk of fracture. 

My NTX test result was 123 nmol BCE/mmol creatinine. (Reference range: 4 - 64 nmol BCE/mmol creatinine)  Uh-oh!     



              "Dont' give up. It is still your turn to be in this world."
                                                                   Crucibles of Will


*  Taking a thiazide diuretic didn't seem like a good idea even way back then when I didn't know much about osteoporosis. Now, with about seventeen years of experience with this disease and working with patients with bone loss for at least ten, using thiazides to limit urine calcium loss seems like an even a worse idea. Thiazides interfere with trace mineral absorption, especially magnesium and zinc. Potassium depletion is very common with thiazides and can cause heart arrhythmias and glucose metabolism problems...not something you would want to have, especially if you are running marathons and competing in Ironman triathlons. Simply adding more vegetables to a person's diet and having them supplement with boron, potassium and vitamin K-2 MK-4 almost always lowers urine calcium losses. A much safer approach.



Friday, October 13, 2017

Supplemental Calcium for the Prevention and Treatment of Osteoporosis: New Guidelines by the EMAS


Eye opening stats:
-  Approximately 50% of women and 20% of men will become osteoporotic and suffer some type of fracture within their lifetime.
-  Spine and hip fractures can be debilitating, life changing events leading to long term pain and rehabilitation.
-  Twenty-eight percent of women and thirty-seven percent of men who sustain a hip fracture die within a year.

What can be done?:
These abysmal numbers DON'T have to be that way! Osteoporosis, for the most part, IS preventable. We do NOT have to see such large numbers of fracture rates if we could increase awareness and focus on prevention. Leading a healthy lifestyle is extremely important for reducing osteoporosis risk. This includes good nutrition, maintaining regular physical activity, and not engaging in destructive alcohol, tobacco and/or drug use. Along with eating a healthy diet high in fruits and vegetables and adequate protein, sufficient calcium intake is extremely important for bone health.

But what if a person already has osteoporosis and they are 60, 70 or 80 years old? Is there no hope for them? Is prevention the only thing we can do? NO! In fact I just spoke with an very nice 78-year-old woman tonight who has sustained multiple fractures of her spine and a hip fracture. She was distraught that there might not be anything that could be done for her...that she would simply have to live in fear of more fractures and continued pain. I have been working with patients with osteoporosis for almost 20 years now and have seen other patients with similar scores and in similar situations. And I know for a fact that there IS a lot that can be done to help. That there IS hope and PLENTY of it. But we can't be passive. We need to attack situations like hers from ALL directions. But improvement CAN be had...slow and steady, like putting
At 17,500 feet on Mt K. "Just Keep Going"...and you will get there.
one foot in front of the other. But it will happen. We just need to get up EVERY day and do things to improve. Slowly, slowly...just keep grinding away...but yes, improvement will come. Not to get too off track here but I think this is why I so love challenges like competing in Ironman triathlons or running up Mt. Washington, or Mt. Kilimanjaro. These goals are long and arduous, and rewards come from "just keeping on going".

There are lots of pieces to the complex puzzle of osteoporosis. Mineral intake is just one of those pieces. I must admit that I rarely write about supplemental calcium but a newly released clinical guide for the prevention of postmenopausal osteoporosis by the European Menopause and Andropause Society (EMAS) prompted this blog.

We all know that calcium IS necessary for strong bones but recent epidemiological studies linking excess calcium intake with "possible" cardiovascular risk has confused the waters. Many patients and doctors alike are questioning if supplemental calcium is safe and indeed if it is necessary at all. In response to these questions, the EMAS released new, updated guidelines. The following is a summary of the publication's most important points:


Insufficient calcium intake
   increases fracture risk AND an
   adequate daily intake is
   important for preventing 
   osteoporosis.

-  An intake of 700 to 1200 mg of
    calcium every day is important.

-  When possible, dietary calcium
    should be the preferred choice
    over supplemental calcium.

-  If dietary calcium intake is
    insufficient, supplemental
     intake is recommended.

-  Data from the National Health and
    Nutrition Examination Survey
    (NHANES) database shows that
     less than one-third of women 
    consumes enough calcium from
    their diet.

-  Excess intake of calcium does not
    help to reduce fracture risk.

There is no conclusive evidence
    that excess calcium intake causes
    harm.  [It is our opinion at OsteoNaturals that large doses of calcium (over 500 mg)
    should not be taken at one sitting, and that total daily supplemental intake be limited
    to 600 to 1,000 mg over the course of the day (depending on how much calcium is
    obtained from the diet).]

There is no doubt, CALCIUM is VERY IMPORTANT for skeletal health and not just for the prevention of osteoporosis but also for its treatment. The problem with relying on dietary calcium is that absorption of calcium from food does not exceed 35%. For this reason alone, calcium supplementation is a good idea. Adequate calcium intake is important, not just when we reach age 50, and not just when we have been diagnosed with osteopenia or osteoporosis...but when we are young and healthy! It is difficult to obtain sufficient calcium from diet alone, so no matter how you cut it, calcium supplementation is the best way to ensure sufficient intake.

Many patients do not adhere to calcium recommendations by their doctors because supplements are often poorly tolerated. Inexpensive drugstore-brand calcium products are especially difficult to absorb. Constipation, abdominal cramping and bloating are common side effects of calcium supplements. The reason for this is that most of these products contain cheap calcium sources such as calcium carbonate, dolomite, and/or oyster shell calcium. Not only are these forms of calcium not well tolerated but their absorption is low.

Take home message...check labels before purchasing calcium supplements...eat calcium-rich foods...and take quality supplemental calcium. Your bones will be healthier and stronger for it.


Cano, A., et al. Calcium in the prevention of postmenopausal osteoporosis: EMAS clinical guide. Maturitas https://doi.org/j.maturitas.2017.10.004.







Monday, September 25, 2017

DX Severe Osteoporosis: Part V -- A Race of a New Kind




This is Part V of a multi-part essay about my own personal experience with osteoporosis. I will be taking you through the diagnostic and treatment phases of my care in hopes that it provides you a better understanding of osteoporosis in general, and pearls that you can use to better your own bone health. 


"Without struggle, without enduring pain, there can be no full awareness of one's being."
           Crucibles of Will



I had never lost my self-image as an athlete, even as I approached middle age. It's natural for most men in the prime of their life to think they are fairly invincible. I certainly did. My time as an Olympian and decades of competing in triathlons and road races erased any sense of mortality that I may have had. Osteoporosis--my bones dissolving from the core--just didn't fit.

The best thing that could ever happen to me was someone doubting my ability to do something. Ben (not his real name) a close relative of mine once said, "You won't ever make the Olympic Team." And there was another time when I wanted to get into horse racing and he said, "You won't even get a horse to the track, let alone win a race." His words would cut deep; they would linger in the pit of my gut, in the deep recesses of my bones. From that point on, you could try, but you couldn't stop me. I might not be the best in the Olympics and my horse might not have the legs of Secretariat, but I wasn't about to fail and I would just about die trying to succeed.

When I started searching for the causes of my osteoporosis I began to wonder if this trait of mine, my intensity, could have somehow contributed to the severity of the bone loss. Many serious health disorders are caused by multiple factors; life style and stress are certainly major contributors to disease. Whether from emotional or physical causes, stress stimulates a huge release of cortisol from the adrenal glands and it weighs heavy on the immune system. Just a cursory internet search into the causes of bone loss brings up the damaging effects of excess cortisol, the stress hormone, and the involvement of the immune system in bone remodeling.

Many different aspects of who you are and how you live either contribute to health, or lessen its hold. The daily patterns of ones life as it is seen over the span of years can often shed light on who we are...who we have become. Since childhood the dominant pattern for me--and, coincidentally, the cause of why I had to go seek the help of an orthopedist for my hip pain when this whole mess started--was that of my athleticism. I was a hard grinding athlete who believed that it wasn't just the quality of the effort that mattered but it was the quantity of miles that would make me the best. With this erroneous training method, I racked up way to many miles and was constantly in a state of over-training. A ten-mile run usually wasn't good enough...it had to be twenty. And a 75 mile training session on my bike probably wouldn't do when thoughts of my competitors somehow getting an advantage over me during the night as I wasted valuable time sleeping. No, that just wouldn't be enough. I HAD to go 110 miles instead. Usually, this was with no food and minimal fluid and electrolyte replacement. That is how I trained and lived, for decades. It wasn't that I was trying to be foolish or irresponsible; it was just that back then (forty years ago) there weren't a lot of athletes putting in the miles I was and there had been minimal research and awareness into the detrimental effects of over-training and the need to refuel and allow the body to rest. Rest was just a dirty word to me. I was simply totally focused on training hard...not on taking note of the needs of my body. Recovery wasn't in my vocabulary. If I wasn't totally flogged by the end of a training day (and days off were non-existent) then my competitors might be getting a jump on me...or at least that is what I thought.

Throughout high school I ran on the cross-country and track teams, swam on two different swim teams, and rode hunters and jumpers at our farm and in horse shows. Three run workouts a day, even during the "off" season, were more the norm than the exception. A two- or three-hour run, making a bee-line to a distant hill on the horizon, was my fun for an afternoon. Eating, replenishing my bones, was not on my radar. 

Each mile I ran felt like it fueled some magical fire that was deep within me. It was as if my body was
a furnace built to carry this fire and that my earthly life was a burning. I didn't really see my body as a furnace that sometimes needed repairs and maintenance, I only looked forward to the burning. I only knew that the harder and longer I ran the hotter that fire seemed to get until an alchemy of sorts would take place. With the intensity of each run I became a crucible that got hotter and hotter until an amalgamation of all the forces within me and all the natural forces that surrounded me, came together, as one. I knew only one thing as I ran, that the intensity by which I ran nurtured that small burning coal that was in me. A coal that we all have within us, that we are all born with, and which will take us where ever we want to go. When I ran, ran hard, I would blow those coals into flame...into what I thought would be an inextinguishable fire.

Now, it looked like I might have been wrong about the inextinguishableness of that fire. Now I was at the starting line of a new race, one to figure out why I had osteoporosis, and it was a race against time. Sooner or later things were going to start crumbling, and I needed to find a way not only to stop the disintegration but to reverse the damage before the infrastructure started breaking down. And there were bigger threats. Early osteoporosis has a high correlation with other diseases such as diabetes, cancer, heart disease, and Alzheimer's. Once you're caught in an avalanche, once cramps seize up your muscles during a race, once a fire starts dwindling...it's usually all over. The stage was being set in my body; it was easy to see what would happen if I couldn't change the course it was on.
With a T score of -4.3 my spine looked worse than a 100-year old's, but I was determined to put out this metabolic fire that was consuming my bones, and find a way to help them heal, if I could.

Bone densitometry is the gold standard for defining bone loss and determining fracture risk. If your density is low, you are at a greater risk for breaking a bone. When really low, like -4.3, it doesn't take much trauma to break something. A T score of -1.0 or better is normal. Between -1.1 and -2.4 is osteopenia and -2.5 or worse is considered osteoporosis. Anything below -3.5 is considered severe osteoporosis. At -4.3 and as a 46-year-old, I knew I was in for a rough ride.

The next few months were, indeed, bumpy. I had difficulty finding ways to educate myself in depth about the disease, and about all the bodily processes skeletal health, or lack there of, seemed to be involved in. I also had to identify the lab tests that would help lead me to the cause of my bone loss and to monitor progress. Then there was the treatment plan, one I felt would have a good chance of success because it would be tailored, individualized. A plan based on healing my whole body, not one relying only on drugs that built up bone density while ignoring or compromising overall health. My plan would be comprehensive, fine-tuned, based on how my particular body works, paying attention to its underlying functional patterns. I wanted to get this ALL figured out before I really started breaking things...but that didn't happen.

The Medical Scene:

After the two rib fractures while cross-country skiing, I sustained a mild compression fracture of a mid thoracic vertebra. In retrospect (isn't that always the way it is) I guess I shouldn't have been lifting that couch. In a medically inquisitive way of thinking, it was an "interesting" experience. It "felt" like a "pfffst"...like air rushing out of a blown tire when the vertebra broke. From a personal way of thinking--it wasn't actually interesting at all--just painful and distressing. When I told the endocrinologist about the fracture he wanted to see me right away. I didn't know why. As a chiropractic physician who has seen lots of compression fractures in patients over the years, I knew there wasn't much a medical doctor could do to help. But I went in to see him anyhow.

Health care should be a little less like processing cattle and more of an investigation of what is happening to real people with real hearts and real feelings. You have probably sensed the same, especially at the beginning of each doctor's visit. Each appointment always begins with allegorical weigh-in and measure. As if they are saying, "Yes, you are NOW at the doctor's office."

Being a doctor, the medical scene was completely familiar to me. (Although I don't weigh and measure patients at every visit unless it is warranted.) At the same time, the assumption was that now I was the patient and I would go along passively with whatever my doctor recommended. In general, this is the expectation of what patients should do, and it works out well much of the time. Most patients either don't actively engage in their own health are, or they just ask a few questions and look up some articles on the Internet. The medical jungle is daunting to the lay person. The amount of information available and the technical language it's encoded in shuts down just about any attempt to engage with it. For most people, it is hard to explore this territory and stay oriented. Amidst the confusion and complexity, it is easier to get lost than to stay on the trail. But I had a major jump on the game. I didn't know much about osteoporosis, but I could speak the language.

The endocrinologist that I had found at UConn seemed more like a coach than a guarded, emotionless physician. Of course he still had his nurses weigh and measure me at each visit--we couldn't do without that--but from the beginning he let me know he was on my bench. He was direct and told me he had never seen anyone with the extreme low bone density that I had who did not have multiple fractures. He never seemed to be rushed and would always take time to listen to my thoughts and concerns. Best of all, he didn't have those invisible blinkers strapped to the side of his head. He was willing to consider things from all angles, and to help me take this to any level of investigation that I wanted. Now with this compression fracture, I realized that he wanted to see me because he wanted to reassure me that we would find the underlying cause of this mystery and that I wasn't alone in this mess. He also explained the surgical procedures, vertebroplasty and kyphoplasty.

Once a person has sustained one compression fracture, the chances of them sustaining another within a year increases 4- to 6-fold! This phenomena is referred to as "vertebral fracture cascade" and he wanted to avoid this at all costs. Once several vertebra collapse a person's posture becomes kyphotic, bent forward, and this can eventually compromise heart and lung function when the kyphosis becomes severe.

Compression fractures of the spine can result from major trauma such as falling backwards onto the buttocks, or from minor traumas such as bending, lifting, coughing, or twisting. When bone is EXTREMELY fragile, fractures can result from simply walking around or, as with the second compression fracture I sustained, bending forward to pick up a stick when running. When the spine structure is severely weakened, it doesn't take much strain at all for the vertebrae to simply collapse.

Both of my compression fractures gave me a fair amount of pain for about a year. But it is not unusual (nearly 50%) for vertebral compression fractures to cause minimal or no pain and may go undetected. In fact, many of these fractures are discovered as "secondary findings" when radiological procedures are being performed for other medical reasons. (Tip: if you have had radiographs taken and read at a medical facility, it is a VERY good idea to have your chiropractor double check them.)

So how do you know if you have sustained a vertebral compression fracture? Typically your chiropractor or medical physician will be able to find a localized area of tenderness when they are examining your spine. He or she may also notice an increased kyphotic or forward angulation in your spine if there is a fracture in the thoracic area. Thoracic and lumbar spine fractures are the most common areas of the spine to sustain compression fractures although they can occur in the cervical region also. If your doctor suspects a fracture, x-rays will be ordered. A bone scan, CT (computed tomography), and/or MRI (magnetic resonance imaging) may also be indicated to determine if the fracture has occurred recently or if it is old and occurred months or years ago. These tests can also help your doctor evaluate any neurological involvement and also to rule out any suspicion of cancer.

The endocrinologist explained to me that if the compression fracture was severe enough they could inject cement directly into the vertebral body to reduce the pain and stabilize the fracture, a procedure called a vertebroplasty, or use a balloon to expand the fracture prior to injecting the cement. This second procedure, a kyphoplasty, attempts to bring the collapsed vertebra back to its original size. After assessing the fracture, he determined that it was not in need of either procedure. (Whew!)

At that time, 18 years ago, these surgical procedures were becoming a common treatment for compression fractures. But more recently, they have come under considerable scrutiny, not only due to the significant risk of adverse effects such as bleeding, infection, allergic reactions, and leakage of bone cement into the surrounding tissues, but also regarding questions concerning their long-term benefit. In fact, many believe that these procedures may increase the risk of the fracture cascade by placing undue mechanical stress on adjacent vertebrae.

In 2010, the American Academy of Orthopaedic Surgeons actually recommended against using vertebroplasty and only gave a weak recommendation for kyphoplasty.(1) In 2013, a study by Martinez-Ferrer et al.(2) published in the Journal of Bone and Mineral Research showed that there was a 30% chance of sustaining another compression fracture after a vertebroplasty. They also found that leakage of cement into the disk beneath the vertebra being repaired contributed up to a six-fold increased risk for developing a new vertebral fracture. When hard cement leaks into the disk this places increased mechanical pressure on the vertebra below. The authors state that other comparative studies indicate a similar problem with kyphoplasty.

As a chiropractor, I wasn't too keen on surgical procedures or drugs. Certainly in the case of the vertebroplasty or kyphoplasty, these would not have been my first choice even if they had been recommended by the endocrinologist. Chiropractors as a general rule are dedicated to the goal of genuine healing. We are not satisfied with eliminating symptoms by suppressing them or by short-circuiting the body's patterns of functioning. Chiropractors support the body's innate ability to heal, and feel that drugs and surgery should be used only as a last resort. Sometimes these interventions are a necessary part of treatment, but even then, there is a lot that can be done to strengthen the body through conservative means. In my case, I wanted to try to find the underlying causes of my disease and to address them. I wanted to give my body the best possible chance to heal itself. Most of the other doctors I saw had different ideas so I always had to reel them back in and get them headed in the right direction...the direction I CHOSE for treatment.

Genetically speaking we humans were only designed to live for thirty-five years or so. After that, after we have procreated, we really didn't have much reason to live...genetically speaking that is. Bone density follows this script and only actively increases up to about age 35; after that bone is still actively replaced, but only maintains the density it achieved earlier. Eventually this density starts to decline, and my density had been declining for years--possibly decades. In terms of nature's plan for my bones, there was nowhere to go but down. I, on the other hand, had other plans in mind.

               "This is why I run: for the sake of the fire; for the burning."


1) The Treatment of Symptomatic Osteoporotic Spinal Compression Fractures ̴ Guideline and Evidence Report. Adopted by the American Academy of Orthopaedic Surgeons Board of Directors, September 24, 2010. http://www.aaos.org/research/guideline.pdf and http://www.aaos.org/news/aaosnow/oct10/cover1.asp

2) Martinez-Ferrer, A. et al. 2013. Risk factors for the development of vertebral fractures after percutaneous vertebroplasty. Journal of Bone and Mineral Research 28(8):1821-1829.

Tuesday, September 5, 2017

DX Severe Osteoporosis: Part IV -- Zebras



The Will

"Sometimes you don't know how deep inside you can go until you put yourself in a place where there is nothing between you and the mirror in front of you to blur the image; a mirror that shows not just your form, but your capacity--what you are made of. To give off light, along with passion you also need will. Will carries you through hard times and loneliness when no one else believes you can accomplish what you have set out to do. The will focuses the flare of passion, it is your navigator, the director of our life force, the hands that tend your flowering. Like the skeleton, will gives you form. It doesn't just support your movements, nor is it just a reflection of your musclular capabilities, but your will defines the absolute raw intensity of your nature, and by this you can bring into being all that lies within you as potential."
Crucibles of Will


This is Part IV of a multi-part essay telling you about my own personal experience with osteoporosis.


Zebras

After receiving "the diagnosis" I realized I had been getting signals for some time that something was wrong. My hands and lower back ached constantly; I had about as much energy as a dog in August; and felt cold all the time, as if it were perpetually January. My skin, especially on my chest and arms was incredibly sensitive and I hated being touched in these places. I was irritable and I guess I was depressed, although I would have denied it completely. Sharp noises or gentle pokes from my children during play caused a sickening wave of adrenaline response to course through me. The two fractured ribs I sustained while training for the American Berkebeiner, a 50-kilometer cross-country ski race in Wisconsin, now made more sense. I had just been pulling hard on the ski poles going up the hills...no falls, no direct trauma; just intense muscular shear forces on the now obviously structurally unsound bone.

The newly discovered frailty also began to take its toll on my professional life as a chiropractor. Every time I entered a treatment room I felt as if I were taking on a sumo wrestler...heaven forbid if the patient was 6 feet plus and weighed over 200 pounds. Chiropractic treatment in general is very precise and gentle, but it does require some motions that impart more physical stress to the doctor than they do to the patient. Even when treating normal-sized adults, adjusting them would send shock vibrations rattling through me. It was as if my resilience and strength had faded away, and it wasn't the running shoe that was broken down in the morning, it was me.

Lab tests are an important source of information, not only about what is going on inside a body, but also about what isn't going on. Over the next five years laboratory testing would play a huge part in my life as I tried desperately to find out not only why I had osteoporosis but how to fix it.  Severe osteoporosis (-4.3 T score on bone density examination) in a relatively young male is rare. For several weeks after the initial diagnosis the endocrinologist thought there may be a more serious disease process lurking and that it was the source of the unusually severe bone theft from my body. The list of diseases that can cause extensive bone loss is very long. From the common condition where one of the parathyroid glands becomes overactive (hyperparathyroidism), to the deadly bone-destroying multiple myeloma. We had to rule each of them out. Initial lab work helped eliminate most of the dreaded disorders. The only real clues we came up with were that my urine was rich in calcium and had large amounts of bone collagen in it, the result of active bone destruction--way too much of it.

There is an old saying, "When you hear hoof-beats, don't think zebras." In other words, if you hear hooves behind you, don't expect to see a zebra when you turn around...it will probably just be a horse. Dr. Theodore Woodward, a medical doctor in the 1940s, coined this phrase as a way of encouraging fellow doctors not to delay treatment by looking for rare, complex diseases at the beginning of the differential diagnostic process, because in all likelihood, the patient's symptoms are probably being caused by something simple and easy to treat. There is a lot of truth to this...although sometimes, there are zebras.

To rule out the systemic mastocytosis the doctors had to drill a hole through my bone and take out a core sample to look at under a microscope. As an added benefit to this procedure, it was also a good way to see how my bones were really holding together and to assess the quality of my bones. 

Normal bone on the left. My biopsy on the right.
During the two weeks before the biopsy, I took two short courses of oral tetracycline. This would be absorbed into my bones and used as markers for the lab to determine the pace at which my bone was being made. The bone tissue was taken from the right side of my pelvis. The surgeon from UConn Health Center first injected a local anesthesia into the area, made a small incision and then, with a hollow hand-drill called a trephine, began drilling through the bone. The trephine was shiny but still medieval-looking, and had a rudimentary handle on one end with large jagged teeth on the other. The doctor took her time twisting the trephine; I could feel the teeth as they passed through each layer of bone. She explained that it was easy to damage the sample; osteoporotic bone is fragile, especially the trabeculae--the lattice of three-dimensional structural beams sandwiched between the inner and outer cortex that give bone its ability to be light yet strong. Trabeculae are designed to withstand the forces of normal activity, like running, but not drilling. If she used too much force, the trabeculae would snap and the pathologist would not get a good picture of their integrity, their "connectivity."

I must admit, having a hole drilled through my pelvis was unnerving. I know it really wasn't a major procedure, patients have a lot worse things done to them. It didn't even hurt that much except for the injections of anesthesia through my abdomen to help numb the inner part of my pelvic bone. But the whole procedure just seemed crude. My response had nothing to do with the doctor; she was extremely sensitive, caring and competent. Maybe it was the sedative she gave me, but during the surgery I kept thinking about the ancient Indians of South and Central American, and how archeologists have discovered skulls with holes drilled into them. Holes that had healed around their edges, indicating that the people/patients had been alive when the procedures were performed. Although they were performed with the intention to heal, it had to have been excruciatingly painful--such an invasion, an assault upon those individuals. What was being done to me had been done to them long before--the drilling-- the same procedure of a person twisting a tool into the inner physical being of another.

The doctor finally broke through the inner bone cortex to the softer tissues underneath, and pulled out a 3/4 inch, pencil-thick, piece of bone. She placed it carefully into a small bottle of chemical solution and handed it to me. I had never seen a piece of my body like that before. It was all so odd to me.

I had been told that the aftereffects would not be any worse than if I had bumped my hip into a kitchen counter. That description might have been accurate, but only if I had been running twenty m.p.h. through my kitchen when I hit it. For the next three days I dragged my leg around like a lead weight; I couldn't even think about running for two weeks.

Trabeculae in bone should be plentiful, robust, and intact. What we found when we looked at the biopsy slides was that mine were few in number, thin, and disconnected. In a crime lab with just bone to look at, a technician would have pinned me as a 100-year-old malnourished female. Rapid loss of bone does that to trabeculae. When osteoclasts become aggressive, devouring excess bone and leaving large deep gouges in the bone surface, even normal functioning osteoblasts are incapable of fully filling in the holes with new bone. The result is pitting in the cortex of the bone and trabeculae that get thinner and thinner until they separate from adjacent bone.

Looking at my bone biopsy under the microscope, we could see a lot of the trabeculae just hanging there like stalactites and stalagmites giving no strength at all to the bone. It was similar to the beech trees in New England that become weakened by a fungal pathogen. Hidden from view just under the bark, the beech's inner structural core is silently being eaten away. To the untrained eye, the trees appear healthy enough, beautiful majestic giants in the forest, until a small wind topples them over...the result of "beech snap." Osteoporosis is similar. Often silent, often afflicting healthy appearing individuals, but underneath hidden from view are overzealous osteoclasts eating away, like a fungus, at the structural core.

As with the wood in "beech snap," trabeculae, in osteoporotic bone, become incapable of resisting the stresses of everyday life. Hips snap and the spine crumbles, and like the broken beech that can't regenerate, the trabeculae can never re-attach. The manner by which bone forms does not allow for it to develop where there is nothing but empty space. This is where all those articles I had read about severe bone loss being "irreversible," began to make sense. But I did not want to accept that. I wanted to find a way around this seemingly impossible physiological impasse. There had to be a way, not just to gain back density by using a drug, but to gain back both the bone density and the structural integrity of newly remodeled bone.

The biopsy ruled out mastocytosis but actually brought up more questions than it did answers.
Zebra striping. Intermittent bone formation.
Besides having disconnected trabeculae, my bone had an odd appearance. The biopsy report called it "zebra striping," or intermittent bone deposition. There would be up to four layers in some areas, with new bone and then no mineralized bone, then bone, then no mineralized bone. It looked like the layers of different soils at an archeological dig. The endocrinologist estimated that the time-lapse between each stripe was days or weeks, not months. Neither the pathologist who read the biopsy nor my endocrinologist knew what to make of the queer stratification. They had seen this striping before on rare occasions with metal toxicity, but the biopsy had been stained for aluminum and iron and it came out negative. Lab testing of blood, urine, and hair for other heavy metals came up negative as well.

It was becoming clear to me that the only way to track down and destroy the beast that stole my structural strength was to immerse myself deep in the study of osteoporosis. I wasn't about to leave this solely in the hands of doctors who would drop me into a file drawer and leave me there for weeks and months at a time. I began to read everything I could about bone biology, and specifically, osteoporosis. I went to osteoporosis seminars and week-long conventions. I took courses on how to read bone density exams. I joined the American Society for Bone and Mineral Research, the International Bone and Mineral Society, and the International Society for Clinical Densitometry. I had dissected a lot of human cadavers in anatomy class at chiropractic school so I knew what it was like not only to study something intensely, but to pick through each and every part of a very complex puzzle. I wasn't just going to study this disease, I was going to rip it apart, piece by piece, clue by clue. Like a dog kicked into a corner, (s)he will come out fighting. I may have skipped a few beats when I first heard the words "severe osteoporosis" as my diagnosis, but my heart quickly rebounded, pounding like a competition-starved athlete ready to do battle. I was sure this beast wasn't much tougher than some of the big ugly guys I had competed against when I was vying for a spot on the USA Olympic Team. I might not win but I sure as hell would attack with everything I had, even down to the center of my physical being, down to my bones. Or at least what was left of them.

"When you go to the core of anything, you go to the heart of its reality, its truth, its real substance."



Saturday, September 2, 2017

Is Prolia the right choice to help reduce fracture risk ???

When faced with fractures from severe osteoporosis, taking a bone specific medication to gain bone density (and hopefully bone strength) can be warranted, at least in the short-term. Prolia (denosumab), or one of the four available bisphosphonate medications on the market, are typically the options given by medical doctors for treatment of osteoporosis. None of these drugs are great--they can all cause mild to severe adverse side effects and long-term use can lead to atypical femur fractures and osteonecrosis of the jaw (ONJ)--but in some severe cases, when fracture risk is extremely high, we just have no choice but to use a medication. More and more doctors are beginning to prescribe Prolia, and less so the bisphosphonates. The reason for this is that studies show Prolia to increase bone density more so than the bisphosphonates. But...there is a hitch. (There usually is when it comes to drugs.)

Prolia is a human monoclonal antibody that inhibits an immune protein called RANKL. (Dr. McCormick talks about RANKL in his book, The Whole-Body Approach to Osteoporosis.) RANKL stimulates osteoclast cells to
resorb (break down) bone. By limiting the body's ability to produce RANKL, Prolia is able to effectively reduce osteoclastic bone resorption and increase bone density. The problem is that RANKL is also needed for the immune system to work properly. So by limiting RANKL production we see immune related side-effects such as muscle and joint pain (inflammation), nausea, diarrhea, headache, skin irritation, skin blistering, fever/chills, dizziness, numbness, urinary tract infections, abdominal pain, elevated heart rate...etc....etc....

But side-effects may not be the worst thing about USING this drug...it may be from STOPPING this drug. In a review of the literature, the European Calcified Tissue Society (ECTS) found that when Prolia is discontinued there is "a rapid decrease of bone mineral density (BMD) and a steep increase in bone turnover markers (BTMs)". Case studies show "multiple vertebral fractures, after discontinuation of denosumab."

Analysis of the FREEDOM and FREEDOM Extension Trial suggests "the risk of multiple vertebral fractures may be increased when denosumab is stopped due to a rebound increase in bone resorption." "Clinicians and patients should be aware of this potential risk."

This rebound effect makes taking Prolia short-term not an option unless it is backed up by a minimum of 6 to 12 months of a bisphosphonate.

Tsondi, E. et al. 2017. Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS,
Bone Aug 5;106:11-17.

Wednesday, August 30, 2017

DX Severe Osteoporosis: Part III -- Looking to the "Whole" for Answers




"It is not by sending his awareness out beyond the natural world that the shaman makes contact with the purveyors of life and health, nor by journeying into his personal psyche; rather, it is by propelling his awareness laterally, outward into the depths of a landscape at once both sensuous and psychological, the living dream that we share with the soaring hawk, the spider, and the stone silently sprouting lichens on its coarse surface."


     David Abram, 

     author of The Spell of the Sensuous



This is Part III of a multi-part essay telling you about my own personal experience with osteoporosis.



Part III :  The "Whole"

I knew from the start that I wanted to be informed about, and involved in, every aspect of testing, diagnosis, and the development of a treatment plan for my osteoporosis. Anyone can choose to do this, if she or he is willing and able to put in the time and attention. It was somewhat easier for me because of my medical training but I still struggled and I knew it was important to get the expert help of specialists. The specialists were allies in unknown territory for me. I rounded up the best I could find. I put together my own team to go up against this disease that was my new adversary.


The fourth endocrinologist that I contacted (I found out later) was the "Godfather" of osteoporosis. A doctor world renown for his expertise in osteoporosis and who ended up being not just an amazing doctor to me but also my mentor. I also saw several additional orthopedists because I not only had osteoporosis but my hip pain persisted beyond the time when the micro-fractures should have healed.


While the specialists gave me useful information (especially the endocrinologist) it could be frustrating to try to communicate with them. The very focus that made them experts in their fields seemed to give them a kind of blindness. It was as if they could only see from one point of view, the view given them by their specialty. To me it made sense not to confine my vision to one viewpoint, but to consider my body as a whole. After having been active all my life, I was not used to being shut down physically. Now I had two chronic disorders at once, the hip pain and the bone loss. This got me thinking--could there be a connection between the two? Not that one was necessarily causing the other--the micro-fractures and osteoporosis, yes, but the persistent hip inflammation and severe bone loss?...well...could THEY be from the same underlying mechanism? Could these two entities be caused by the same "poison in the water"?


I put this question to the different specialists I was seeing: a new orthopedist and his in-residency assistant at Boston General Hospital, and also to the endocrinologist at UConn Center for Osteoporosis. But each of them just looked through the eyes of his own specialty. The two orthopedists thought only in terms of bones and joints, focusing totally on the hip inflammation. They ruled out arthritis and Lyme disease, and never once mentioned the word osteoporosis and certainly didn't consider the possibility that there could be a deeper connection between the two entities on the biochemical or body systems level. The endocrinologist thought only about hormonal and metabolic disease processes within the organs that can cause a loss of bone density. He never thought to look at the persistent inflammation in the hip for any clues that might help him find the reason for the osteoporosis.


Like race horses wearing blinkers, if it wasn't right in front of them, if it wasn't in their specialty, then it didn't exist. My suggestion of a possible underlying condition contributing both to the lingering inflammation in the hip and the systemic osteoporosis would have involved crossing lines between specialties. Their minds just could not do that. Modern Western medicine is so bound up in its own laws of associating particular symptoms with particular disease conditions and commonly associated causal factors, that physicians often resist considering any alternate possibilities of connection.


The problem with how the specialists looked at things seemed to be a case of hyper-focus. But when you are looking at your own predicament and trying to find answers, immediate answers, it goes beyond hyper-focus, it goes into desperation. Having that feeling of desperation and focusing too intensely in your effort to find an answer can, and usually does, interfere with your ability to see something that is right in front of you.


Caught in a crisis, desperate for solutions -- solutions now--
it is hard for the mind to let go of the sharp focus. We feel that that intensity of focus is the only way to solve the problem. But in truth, we need to widen our view. We need to stand back--decipher the significant reality that may be cluttered, camouflaged, distorted by dogma and our own hyper-reactive emotions, and take in the "whole" view. In my own practice as a chiropractic physician, I have seen that pushing to make a diagnosis too soon can lead to error. Simply holding the pieces of the puzzle for a few hours or days can help to make the connections between patients' symptoms and my examination findings become clearer. Forcing puzzle pieces together doesn't work. By holding single threads of information, such as the appearance of an x-ray or various results from the lab, and then allowing your focus to widen--to let connections between threads or dangling pieces become clearer--the connections will eventually evolve and become locking pieces to the puzzle. It is by gong back and forth between sharp focus--wide focus--sharp focus, that you allow the diagnosis to develop. It takes time and patience to let the pervasive pattern of energy that runs through each person's system help in connecting the pieces into a whole. All my experience told me that I needed to bring a different kind of vision to the problem of my osteoporosis than that one on which the specialists relied.


I began to see that the trail to recovery would be long. That those moments when I had stood with the two initial orthopedic surgeons looking at the dark x-ray of my hip, that I was standing at the beginning of a long trail through difficult terrain that might (and did) extend for years. Academically speaking, the trail was choked with a tangle of medical information that was hard to decipher. But even more difficult was the psychological challenge of this boulder strewn trail; one where I would stumble and curse through multiple fragility fractures--twelve over the next five years.  

...to be continued...


"The effects of any serious disease ripple throughout our bodies, throughout our lives--throughout everything we think of as the self."
Crucibles of Will





Wednesday, August 23, 2017

DX Severe Osteoporosis: Part II -- A Burning


"Our lives are a burning. The physical processes that fuel and sustain us--breathing and eating--are kinds of burning. Our passion also is a kind of fire. When our lives are lit by our passions, they give off light and heat. In the end our bodies are consumed, and only the gold is left."
                                                                                                  R. Keith McCormick, DC
 

This is Part II of a multi-part essay telling you about my own personal experience with osteoporosis.


Part II A Burning

My first reaction was embarrassment. How could I have this? I'd eaten well all my life: or at least I thought I had. I'd always drunk a lot of milk. I'd never done anything "wrong." I'd always done everything "right" to be healthy. It just didn't make any sense. Osteoporosis--a disease associated with frailty--was the antithesis of who I thought I was. From early on, the foundation of my life centered on developing the strongest, fastest, healthiest body I could. I had always wanted to be an Olympian and it seemed that from day one my attitude had been one of wanting to improve--to be the best, strongest, toughest competitor out there. My body was the vessel by which to achieve this, and I had fueled it with those goals in mind.

I didn't tell anyone of my condition. I was too embarrassed--ashamed of what I had become--a broken-down old man in what I had thought was the prime of my life.

Initially, I struggled, not knowing how I was going to get out of this crumbling skeletal mess. Before I was diagnosed, I felt that I was almost unstoppable and certainly unbreakable. Osteoporosis did not fit with my unbreakable self-image. Now I was afraid I would fracture my spine if I opened the garage door or bent down to pick up something, and certainly shatter if I fell off my bike. Always one to help out at my son's school, moving benches, lifting boxes, building sheds, I began to hide or made excuses. I was supposed to be strong, an Ironman (triathlete), an ex-Olympian no less. And now, just like that, I couldn't move a table. Everyone would surely think I was a wimp!

The voice of the orthopedist, "You should go on disability" and "Now promise me that you'll walk with a cane," made me want to throw up. When I stood before a mirror, no matter how long I searched for that person I used to be, all I saw was emptiness. My self-confidence, as well as my inner structural core, had withered away.

The first endocrinologist I saw read down a list of about twenty diseases and risk factors that can cause severe bone loss, asking me questions after each item. When he got to the bottom of the list, he diagnosed me with "primary osteoporosis" and handed me two prescriptions. One was for a thiazide diuretic to help reduce the calcium loss in my urine, and the other for alendronate (Fosamax), a bisphosphonate to harden my bones. I told him that I wasn't there for prescriptions--I was there to find out why I had osteoporosis--and to fix it.

After calls and e-mails to three more endocrinologists, one of whom wrote back asking for the date of my last menstrual period, I finally made an appointment with one who specialized in the treatment of osteoporosis. The day of my appointment came and, as I opened the door to his waiting room, I stepped into a world that made me shudder. Trying to look invisible, I walked slowly to a chair and sat down. There were three other patients: all older women, all in wheelchairs, each with a dowager's hump indicating spinal degeneration from a series of compression fractures. All three women looked downward. The did not speak. They did not make eye contact with me or each other. Each was withdrawn as though she were collapsing inward. And then it dawned on me. These women were now my peers.

When I left that office, I never looked back. I was on a mission--a mission not only to find out everything I could about my osteoporosis and fix it, but also to gain back my lost self-confidence.

"Frailty has a way of sneaking up on a person. It's like the wear of your running shoes. Everything seems to be going along fine and then you pull up lame because your shoes have worn out -- as if the innersole somehow broke down overnight while you were sleeping."

Monday, August 14, 2017

DX Severe Osteoporosis: Part I -- The Day That Changed My Life Forever



"Glimmering on the edge of death, sweeping in to overwhelm us, is the larger sense of who we are."

   Paul Rezendes
   author of The Wild Within


This is Part I of a multi-part essay telling you about my own personal experience with osteoporosis. I'll try not to be too windy but I will take you through some of the diagnostic and treatment phases of my care. I will offer LOTS of information to help you gain a better understanding of osteoporosis in general, and hopefully even some specifics into your own bone health. 


Part I :  The Day that Changed My Life Forever


I remember the day like it was yesterday...

The doctor put the x-ray up on the view-box...the bones were not white: they were gray--like ashes.

The x-ray of my pelvis didn't light up with the brightness of hard, opaque tissue characteristic of healthy bone. It was dull, and the light that filtered through it, drained the room of substance. There had been barely enough room for an exam table and an old chair, and now it felt claustrophobic. I stood wedged between the two orthopedic surgeons, faces pale and gray in the dim, florescent, hospital light as we stared at the film showing the first hard evidence that something was seriously wrong. "The hip joint itself looks good," the senior orthopedist said, "but the bone looks rare--not much density."

It had been the pain that finally forced me to the doctor's office; the pain that had stopped my running. As an athlete who had trained intensely for over 25 years, running road races, and competing in the sports of modern pentathlon and triathlon, I was used to discomfort and nagging injuries. But this time the pain persisted in a way it never had before. It was in my hip, and at first I thought it was just another over-use injury from running.

But the severity of this injury was more than I could figure out myself...I needed some help.

One look at the x-ray showed an obvious lack of overall bone density. Where there should have been the whiteness of bone, there were the dark grays typical of softer, less-dense tissues. Later an MRI, bone scan, and two bone density exams revealed capsular synovitis with micro-fracturing of the femoral head, and severe osteoporosis of the spine and both hips. Like a ton of bricks, I was totally floored as the bone density technician unprofessionally blurted out, "you have worse bone density than a 100-year-old woman!"

How could I have osteoporosis? I was a 46-year-old man, I had been active all my life, and I had always tried to live a healthy life-style. It seemed to me that nothing I had done had invited this disease, and that I had done a lot that should have prevented it. But here it was. It was too late to shut the door in its face. It had already moved in and was making itself at home. Now I had to figure out how to live with it, how to limit the damage, and how to stop it if I could. And I had to figure it out fast--before it ate away my bones.

(to be continued)

Wednesday, July 12, 2017

N-acetyl cysteine (NAC) is powerful therapy for osteoporosis

N- acetyl cysteine (NAC) is an amino acid with powerful antioxidant activity. Like other antioxidants, NAC can help prevent inflammation and cell damage from free radicals but its healing powers do not stop there. NAC has been shown to be especially helpful at combating bone loss. Studies by Ji, et al (2011) and Yamada, et al (2013) both showed that NAC reduces bone loss from excessive osteoclastic activity, increases bone formation, and lowers fat infiltration into bone marrow which can crowd out bone forming osteoblast cells. By neutralizing free radicals and pro-inflammatory cytokines, NAC can be important therapy for combating osteoporosis. Using rat cell cultures, Yamada showed that NAC can help regenerate bone and concluded that "NAC can function as an osteogenesis-enhancing molecule to accelerate bone regeneration by activating differentiation of osteogenic lineages." Ji concluded that "NAC is a promising potential drug for the prevention
and treatment of osteoporosis...".

OsteoNaturals' OsteoStim is a unique and potent blend of antioxidants, vitamins, milk basic protein and medicinal herbs designed to aid in the reduction of chronic inflammation, encourage normal bone metabolism, and manage the adverse metabolic processes of osteoporosis. It contains a therapeutic dose of 600 mg N-acetyl cysteine.  Three caplets provide:
  • Vitamin D3 (1,000 IU): For improved absorption of calcium. Associated with higher bone mineral density and lower fracture risk. Promotes muscle strength and decreased risk for falls. 
  • Vitamin K2 (MK4 (700 mcg) and MK7 (50 mcg)): Activates osteocalcin, a protein important for bone formation. 
  • Biotin (3,000 mcg): Necessary for cell growth. 
  • Alpha-Lipoic Acid (200 mg): Powerful antioxidant to help reduce the proinflammatory 
  • cytokines that stimulate osteoclastic bone resorption and excessive bone loss. 
  • N-Acetyl Cysteine (NAC) (600 mg): This powerful antioxidant lowers free radicals, major contributors to excessive bone loss. 
  • Taurine (200 mg): Important co-factor for balanced bone remodeling activity. 
  • Berberine (250 mg): Studies indicate this medicinal herb helps prevent bone loss and increase bone mineral density by promoting osteoblast (bone-building cells) formation. 
  • BioferrinⓇ 1000 (250 mg): A low-iron (apo-lactoferrin) natural, biologically active milk protein isolated from whey for reducing oxidative stress, decreasing inflammation, and promoting improved bone mineral density. 
  • MBP® (Milk Basic Protein) (40 mg): A component of milk whey shown to promote bone formation and inhibit bone resorption.* 
  • Milk Thistle (200 mg): Medicinal herb with powerful antioxidant activity to help limit the activity of bone-resorbing osteoclasts.
  • GMO and gluten free.

Yamada, M., et al. 2013. N-acetyl cysteine as an osteogenesis-enhancing molecule for bone regeneration. Biomaterials May 24 [Epub ahead of print].

Ji, H., et al. 2011. N-acetyl-L-cysteine enhances the osteogenic differentiation and inhibits the adipogenic differentiation through up regulation of Wnt 5a and down regulation of PPARG in bone marrow stromal cells. Biomed Pharmacother Aug:65(5):369-74.
 

Sunday, July 9, 2017

Calcium-rich, marine multi-mineral complex (Aquamin) is superior to calcium carbonate in its ability to slow bone loss

In a recently published study in Calcified Tissue International, Orlaith Brennan (Royal College of Surgeons, Ireland) and colleagues, compared the calcium-rich, marine multi-mineral complex, Aquamin to calcium carbonate in an ovariectomised rat model of osteoporosis. The purpose of the
study was to assess Aquamin's efficacy in preventing bone loss. Aquamin is a natural, multi-mineral supplement derived from the red algae Lithothamnion corallioides. Aquamin is rich in calcium, magnesium, and 72 other trace minerals.

This 20-week study compared Aquamin to calcium carbonate in their influence on the mineralization and metabolic activity of osteoblasts (the cells that form bone) in cell culture. Trabecular architecture, bone composition, and the mechanical strength properties were assessed. The study found that "oral ingestion of Aquamin results in less deterioration of trabecular bone structure, mineral composition and biomechanical properties in the tibia of rats following ovariectomy than calcium carbonate." In this animal model of osteoporosis, Aquamin was shown to be superior to calcium carbonate in its ability to slow down the onset of bone loss.

OsteoNaturals' OsteoMineralBoost supplies 250 mg Aquamin.

Brennan, O., et al. 2017. A natural, calcium-rich marine multi-mineral complex preserves bone structure, composition and strength in an ovariectomised rat model of osteoporosis. Calcif Tissue Int. DOI: 10.1007/s00223-017-0299-7.

Tuesday, July 4, 2017

OsteoMineralBoost: A Real "Boost" to Bone Health

OsteoMineralBoost was designed by Dr. McCormick to provide that extra kick to mineral intake and sustained bone health. Providing 140 mg calcium from microcrystaline hydroxyapatite (MCHA) and Aquamin, 85 mg magnesium, 250 mg of trace minerals from Aquamin, and 100 mg betaine hydrochloride, OsteoMineralBoost is one of the most important bone health products on the market.

Ingredients: 
     -  MCHA is a highly absorbable form of calcium with naturally occurring bio-active bone matrix
        proteins and growth factors.
     -  Magnesium (as dimagnesium malate) is important for bone and cardiovascular health.
     -  Aquamin won the 2016 Ingredient of the Year for Healthy Aging at the Vitafoods
        Nutraingredients Awards in Geneva, Switzerland. This award was given "in recognition of the
        strong body of scientific trail data that supports Aquamin and the positive contribution that it has
        made to health." Aquamin is a marine (red algae) multi-mineral complex with bio-active
        calcium, magnesium and 72 other trace minerals. There are over 20 published peer reviewed
        papers exploring the positive benefits of Aquamin in the areas of bone health, joint and
        inflammation and digestive health.
     -  Betaine hydrochloride to aid absorption.


Thursday, June 29, 2017

Miami 2 NYC: Jim Made It!

Yesterday, Jim Brassord of Amherst, Massachusetts rowed past Staten Island, under the Verrazano-Narrows Bridge, through the treacherous ship-filled Upper Bay, past the Statue of Liberty and into the North Cove Marina in Lower Manhattan. This was the culmination of his 59 day, 1601 mile unassisted row up the eastern coast of the United States. Jim started in Miami, logged 30 to 40 (longest day was 49) miles a day for two months and ended his journey in New York City. Wow!

OsteoNaturals was a proud sponsor of this venture which raised money for the John P. Musante Health Center. To learn more about Jim's amazing row go to miami2nyc





Tuesday, June 27, 2017

The Similarities Between "Boosting" Athletic Performance and Osteoporosis Outcomes

I must admit, I was a bit lazy last year. After running a 50 mile trail race, I laid low for the rest of the year nursing a heel injury. But I'm healthy now and back training. As per usual, I've set a few goals for the summer...some triathlons and a few running races. There is something about setting goals that keeps me on track--not just in athletics, but in life. Goals are important; they sharpen your vision, give you focus and help steer you to success.

The goals I set for myself are typically lofty ones. Whether it is competing in an Ironman, running up Mt. Kilimanjaro, or improving my bone density naturally through diet and supplements, they usually aren't easy tasks...but that's what makes them interesting. Besides hard work, I am always in search of ways to "boost" my abilities to help reach those goals. Now I am not talking about performance enhancing drugs in athletics or taking osteoporosis medications to temporarily improve bone density at the risk of adverse effects and building poor quality bone. I'm talking about doing things naturally but effectively. I hope you can relate to some of these ideas and use them to boost your own goal outcomes.

Improving Athletic Performance
Improving your performance in athletics, no matter what sport or activity, starts with making sure your body is healthy enough to sustain training for months on end. If you break down a few weeks before a race, all that training goes out the window.

Common sense suggestions:

First, maintain a healthy gut by eating a good diet and taking supplements. Putting high-octane fuel in the tank...lots of good green veggies, quality protein and plenty of minerals and electrolytes...allows the body to rejuvenate after each workout. Second, exercise regularly and focus on quality workouts. Third, get plenty of sleep. It is during the night-time hours that the body repairs itself and you can do a lot of damage to your body in a hard training session. Finally, keep a positive attitude and be patient.

Boost Suggestions:
I have found a few extra little things besides those basics that enhance my performance just enough to put me on a slightly higher playing field...enough to get me from 2nd place to 1st place in a race. For running and competing in triathlons, that edge or boost to performance comes from three things:
1) The nutritional supplement creatine. Creatine is a naturally occurring substance in the body that helps recycle adenosine triphosphate (ATP) energy. But creatine levels decline as we age making it more difficult to effectively utilize ATP.* Not only does creatine help give us more zip DURING a workout but it helps with after-workout recovery.
2) Strength training. This might include the use of free weights, weight machines, elastic resistance bands, and/or simply resisting against your own weight. A well-executed strength-training program contributes to my feeling strong all over, increases total body mass, reduces the risk of sports injuries and improves core stability. **
3) Ensuring adequate electrolytes. For optimal nerve conduction and muscle contractions you need to have plenty of minerals and electrolytes. Nerves fire optimally and muscles respond best when the body is electrically alive and swimming in electrolytes.

Improving Osteoporosis Outcomes
My quest to improve bone health runs parallel to how I approach sports. I treat this goal as a huge challenge that arouses my competitive juices and makes me SO WANT TO SUCCEED. The key is to stay focused every day on the key factors that will keep bones strong and healthy.

Common sense suggestions:
First, maintain a healthy gut (probiotics, fiber, eliminate food allergens and sensitivities, digestive enzymes if needed), eat a good diet and take supplements. Second, engage in weight-bearing exercise regularly. Third, get adequate sleep. Finally, keep a positive attitude and have patience. Sound familiar?

Boost suggestions:
I have found that a boost to improved bone health comes from similar sources as those that I use to enhance my athletic performance:
1) The nutritional supplement creatine.
2) Strength training.
Muscles release myokines, chemical signaling molecules that tell bones to get stronger. This makes sense. Bones have to be strong enough to take the torque produced by muscles; so muscles and bones have to be in close communication with each other. The stronger your muscles, the stronger your bones will be; taking creatine and engaging in frequent strength training are two of the best boosts to this mechanism.
3) Ensure not just adequate minerals but minerals that can be EASILY deposited into bones AND be transformed EASILY into electrolytes.
(Electrolytes are minerals with an electric charge.) In addition to providing one of the best sources of calcium possible for bone building, OsteoMineralBoost*** contains bio-active calcium, magnesium, and 72 trace minerals (from Aquamin red marine algae). It is easily incorporated into bone tissue, helps preserve bone, and is a natural source of electrolytes...perfect for people who suffer from bone loss...and athletes alike. 

It is my hope that you will use some of these ideas in your daily regimen to kick-start or help "boost" your goal attainment. And, if you haven't set goals yet, what are you waiting for?! Whether you are an athlete or an individual who wants to improve health outcomes, the goal-setting process is needed to understand where you are currently, and where you want to go. The fact that you aren't where you want to be, should be enough motivation.

* We can obtain creatine from our diet but the best sources are fish and meat which are acidic and large quantities of these foods may not be the best way to ensure adequate creatine levels. Because creatine is only obtained through animal products, vegetarians have difficulty maintaining adequate creatine levels. For these reasons supplementing with creatine, especially if you have bone loss, is a good idea. For more info on creatine go to:  http://www.osteonaturals.com/2015/07/creatine-and-resistance-training.html
** Of course, when any exercise program is undertaken by sedentary individuals, they should first check with their physician. In addition to the cardiovascular concerns of starting an exercise program, caution, especially in the osteoporotic individual, should be taken to avoid undue load on the spine or hips. For example, bending forward or lifting weights overhead can put a heavy load on the spinal vertebrae and if bone density is extremely low, this can result in a compression fracture.
*** OsteoMineralBoost provides one of the best sources of calcium possible for bone building...micro-crystaline hydroxyapatite. MCHA has been shown in research studies to contain growth factors for improved bone building activity in people with osteoporosis. OsteoMineralBoost also contains Aquamin trace minerals from red marine algae. Aquamin won the Ingredient of the Year for Healthy Aging at the 2016 Nutraingredients Awards in Geneva, Switzerland.

Tuesday, May 23, 2017

More on the Epigenetics of Osteoporosis

Our DNA's genetic code dictates much of who we are both physically and mentally. Genetics is also a determinant of health – good or poor.  Inherited genetic conditions can be caused by a single-gene defect or by complex factors including multiple genes and impacted by lifestyle and environmental factors. 

Earlier this month I wrote about epigenetics: the impact it has on our health and the possible connections later in life to diseases such as osteoporosis. Unlike our genetic makeup that is "hardwired", our epigenome (the way our genes are regulated and/or expressed) is malleable and can be influenced by the way we live.

In fact, recent findings published in the Journal of Bone and Mineral Research by researchers involved in the Southampton Women's Survey at the University of Southampton in the United Kingdom show that poor intrauterine and childhood growth may affect the epigenetic regulation of genes associated with bone development. The lead author of the study, Nicholas Harvey, stated "The health of a child's bone when they are young can influence the risk of osteoporosis in older age."   
By eating better and making wise lifestyle choices, especially early in life, we can influence our epigenome and prevent certain diseases from manifesting. 

Curtis, E.M., et al. Perinatal DNA methylation at CDKN2A is associated with offspring bone mass: Findings from the Southampton Women's Survey. JBMR. April 17, 2017. doi: 10.1002/jbmr.3153.

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