Saturday, August 11, 2012

Oxidative Stress = Bone Loss

As we age, chronic disease such as atherosclerosis, diabetes, Alzheimers, and others, are not uncommon and go along with our overall decline in functional capacity. Osteoporosis is no exception. In fact, we actually begin to loose bone in our 30s, long before sex hormone production in women begins its decline around the age of 45 or 50. (Estrogen production begins to wan about 5 years before menopause.) This should make us think twice about what really IS the cause of bone loss. There must be something else going on besides low estrogen that causes women to loose bone density. And, yes, there is! A decline in estrogen and testosterone levels clearly affect bone density but this occurs only when the body is under oxidative stress.

Oxidative stress, the production of reactive oxygen species (ROS) without neutralization though adequate antioxidant mechanisms, causes progressive cellular damage. Normal body metabolism actually generates radical forms of oxygen. This is normal and we have built in mechanisms to counteract any damage produced by these endogenous (produced within the body) free radicals. But when other ROS producing factors such as pollutants, physiologic stress, or gastrointestinal dysfunction overwhelm the body's antioxidant capacity the result is oxidative stress. When it comes to bone loss, oxidative stress leads to insufficient production of bone-forming osteoblasts, and a hyper-stimulation of osteoclasts, the cells that degrade bone. Not a good combination if bone density and integrity are to be maintained.

Oxidative stress is a critical contributor to the aging effects on bone and muscle, and it is the number one cause of osteoporosis. Way back in 2007 Grassi, et al., reported at the Proceedings of the National Academy of Sciences that the rise in ROS in bone marrow, as seen with low estrogen levels, increases white blood cell and T cell activity fivefold. These T cells then release copious amounts of RANKL, the potent signaling molecule that stimulates the formation and activation of the bone resorbing osteoclasts. This is the reason we see a dramatic rise in bone loss for at least five years after menopause. And this is where OsteoStim comes to the rescue. This powerful supplement is loaded with anti-oxidants, to help neutralize ROS and reduce the adverse effects of free radicals on bone. Not only that but OsteoStim has bone building compounds such as milk basic protein as well as vitamins D and K.  Check out OsteoStim!

Grassi, F., et al. 2007 Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Proceedings of the National Academy of Sciences 104(38):15087-15092.

Website design and website development by Confluent Forms LLC, Easthampton MA